Effects of Partial and Acute Total Sleep Deprivation on Performance across Cognitive Domains, Individuals and Circadian Phase 英文参考文献.docVIP
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Effects of Partial and Acute Total Sleep Deprivation on Performance across Cognitive Domains, Individuals and Circadian Phase 英文参考文献
EffectsofPartialandAcuteTotalSleepDeprivationon
PerformanceacrossCognitiveDomains,Individualsand
CircadianPhase
JuneC.Lo1,JohnA.Groeger1,2,NayantaraSanthi1,EmmaL.Arbon1,AlparS.Lazar1,SibahHasan1,
MalcolmvonSchantz1,3,SimonN.Archer1,3,Derk-JanDijk1,3
*
1SurreySleepResearchCentre,FacultyofHealthandMedicalSciences,UniversityofSurrey,Guildford,UnitedKingdom,2DepartmentofPsychology,UniversityofHull,
Hull,UnitedKingdom,3DepartmentofBiochemistryandPhysiology,FacultyofHealthandMedicalSciences,UniversityofSurrey,Guildford,UnitedKingdom
Abstract
Background: Cognitive performance deteriorates during extended wakefulness and circadian phase misalignment, and
some individuals are more affected than others. Whether performance is affected similarly across cognitive domains, or
whether cognitive processes involving Executive Functions are more sensitive to sleep and circadian misalignment than
AlertnessandSustainedAttention,isamatterofdebate.
Methodology/Principal Findings: We conducted a 2 612-day laboratory protocol to characterize the interaction of
repeatedpartialandacutetotalsleepdeprivationandcircadianphaseonperformanceacrosssevencognitivedomainsin
36individuals(18males;mean6SDofage=27.664.0years).Thesamplewasstratifiedfortherolymorphism
in PER3, which confers cognitive susceptibility to total sleep deprivation. We observed a deterioration of performance
duringbothrepeatedpartialandacutetotalsleepdeprivation.Furthermore,priorpartialsleepdeprivationledtopoorer
cognitiveperformanceinasubsequenttotalsleepdeprivationperiod,butitseffectwasmodulatedbycircadianphasesuch
that it was virtually absent in the evening wake maintenance zone, and most prominent during early morning hours. A
significanteffectofPER3genotypewasobservedforSubjectiveAlertnessduringpartialsleepdeprivationandonn-back
taskswithahighexecutiveloadwhenassessedinthemorninghoursduringtotalsleepdeprivationafterpartialsleeploss.
Overall, however, Subjective Alertness and Sustained Attention were more affecte
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