Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations 英文参考文献.docVIP

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Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations 英文参考文献.doc

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Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations 英文参考文献

Effectsofrs7903146VariationintheTcf7l2Geneinthe LipidMetabolismofThreeDifferentPopulations PabloPerez-Martinez1,2.,AnaI.Perez-Caballero1,2.,AntonioGarcia-Rios1,2,ElenaM.Yubero-Serrano1,2 , AntonioCamargo1,2,MariaJ.Gomez-Luna1,2,CarmenMarin1,2,PurificacionGomez-Luna1,2 , AldonaDembinska-Kiec3,FernandoRodriguez-Cantalejo4,FranciscoJ.Tinahones2,5,HelenM.Roche6, FranciscoPerez-Jimenez1,2,JoseLopez-Miranda1,2,JavierDelgado-Lista1,2* 1Lipids and Atherosclerosis Unit, IMIBIC/Hospital Universitario Reina Sof?′a/Universidad de Cordoba, Cordoba, Spain, 2CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain, 3Department of Clinical Biochemistry, Jagiellonian University Medical College and the Off-Patients Clinic for Dyslipidemia and Obesity Treatment, Krakow, Poland, 4Biochemical Laboratory, Hospital Universitario Reina Sof?′a, Cordoba, Spain, 5Servicio de Endocrinolog?′a y Nutricio′n, Hospital Cl?′nico Virgen de la Victoria, Ma′laga, Spain, 6Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute,UniversityCollegeDublin,Dublin,Ireland Abstract Background:TCF7L2rs7903146isanimportantgeneticfactorpredictingtype2diabetes(T2DM)whichhasalsobeenlinked to higher cardiovascular risk. To date, there is little information about the additional impact of this single nucleotide polymorphism(SNP)beyondglucosemetabolism. Methodology/Principal Findings: We studied whether rs7903146 influenced postprandial lipid metabolism in three differentpopulations(healthyyoungmen,metabolicsyndrome(MetS)patientsandelderlypersons).Eighty-eighthealthy malesweresubmittedtoasinglesaturatedfattyacid-richtestmeal.Additionally,110middle-agedMetSpatientsand20 healthyelderlypersons($65years)weresubmittedtothreedifferentdietarymodelsfollowedbytestmeals.Minorallele homozygotes for rs7903146 showed a worse postprandial lipemia profile in young males, as seen by a lower HDL- cholesterolandApoA1concentrationduringthepostprandi