EGR-2 Is Not Required for In Vivo CD4 T Cell Mediated Immune Responses 英文参考文献.docVIP

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EGR-2 Is Not Required for In Vivo CD4 T Cell Mediated Immune Responses 英文参考文献.doc

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EGR-2 Is Not Required for In Vivo CD4 T Cell Mediated Immune Responses 英文参考文献

EGR-2IsNotRequiredforInVivoCD4TCellMediated ImmuneResponses HildaE.Ramo′n1,PedroJ.Cejas2,DavidLaRosa1,AdeebRahman1,JohnE.Harris3,JidongZhang1, ChristopherHunter4,YongwonChoi2,LaurenceA.Turka1*¤ 1Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 2Department of Pathology and LaboratoryMedicine,UniversityofPennsylvaniaSchoolofMedicine,Philadelphia,Pennsylvania,UnitedStatesofAmerica,3DepartmentofDermatology,Universityof PennsylvaniaSchoolofMedicine,Philadelphia,Pennsylvania,UnitedStatesofAmerica,4DepartmentofPathobiology,UniversityofPennsylvaniaSchoolofVeterinary Medicine,Philadelphia,Pennsylvania,UnitedStatesofAmerica Abstract Background:ThezincfingertranscriptionfactorEGR-2hasbeenshowntoplayanimportantroleintheinductionofTcell anergyandtheregulationofperipheralTcelltolerance.Invitro,apriorstudyhasshowthatTcellsdeficientinEGR-2are hyperproliferativetoIL-2andproduceelevatedlevelsoftheeffectorcytokineIFN-c.EGR-2deficientmicehaveincreased levelsofCD44high Tcellsinperipherallymphoidorgans,andwithage,developautoimmune-likefeatures. Principal Findings: Here we show that despite increased numbers of cells bearing an activated CD44highCD62Llow phenotype,TcellsfromyounghealthyEGR-2deficientmicehavenormalproliferativeandcytokineresponses,andthemice themselvesmountnormalimmuneresponses againstminorhistocompatibility antigens, andthepathogens Toxoplasma gondiiandlymphocyticchoriomeningitisvirus. Conclusions: Our results indicate that EGR-2 is not required to mount normal acute in vivo immune responses against foreignantigens,andsuggestinsteadthatitmayservetoregulatetheresponsetochronicantigenicexposure,suchasthat whichoccurstoautoantigens. Citation: Ramo′n HE, Cejas PJ, LaRosaD, Rahman A, Harris JE, et al. (2010) EGR-2 Is Not Required for In Vivo CD4 TCell Mediated Immune Responses. PLoS ONE5(9):e12904.doi:10.1371/journal.pone.0012904 Editor:JoseAlberola-Ila,OklahomaMedicalResearchFoundation,UnitedSt