Endothelial Lipase Concentrations Are Increased in Metabolic Syndrome and Associated with Coronary Atherosclerosis 英文参考文献.docVIP

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Endothelial Lipase Concentrations Are Increased in Metabolic Syndrome and Associated with Coronary Atherosclerosis 英文参考文献.doc

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Endothelial Lipase Concentrations Are Increased in Metabolic Syndrome and Associated with Coronary Atherosclerosis 英文参考文献

o PL SMEDICINE EndothelialLipaseConcentrations AreIncreasedinMetabolicSyndrome andAssociatedwithCoronaryAtherosclerosis Karen O.Badellino*,Megan L.Wolfe, Muredach P.Reilly, Daniel J.Rader SchoolsofNursingandMedicine,InstituteforTranslationalMedicineandTherapeutics,UniversityofPennsylvania,Philadelphia,Pennsylvania,UnitedStatesofAmerica CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. ABSTRACT Background AuthorContributions:KOBandDJR designedthestudy.KOBandDJR performedtheexperiments.KOB, MLW,andMPRanalyzedthedata. MLWandDJRenrolledpatients. KOB,MPR,andDJRcontributedto writingthepaper. Endothelial lipase (EL), a new member of the lipase family, has been shown to modulate high-density lipoprotein (HDL-C) metabolism and atherosclerosis in mouse models. We hypothesizedthatELconcentrationswouldbeassociatedwithdecreasedHDL-Candincreased atherosclerosisinhumans. AcademicEditor:Tom Quertermous,StanfordUniversity, UnitedStatesofAmerica MethodsandFindings Healthyindividualswithafamilyhistoryofprematurecoronaryheartdisease(n?858)were recruitedaspartoftheStudyoftheInheritedRiskofAtherosclerosis.Bloodwasdrawninthe fasting state before and, in a subgroup (n?510), after administration of a single dose of intravenousheparin.Plasmalipidsweremeasuredenzymatically,lipoproteinsubclasseswere assessedbynuclearmagneticresonance,andcoronaryarterycalcification(CAC)wasquantified by electron beam computed tomography. Plasma EL mass was measured using a newly developed enzyme-linkedimmunosorbent assay. Median EL massin pre-heparin plasmawas 442(interquartilerange?324–617)ng/ml.Medianpost-heparinmasswasapproximately3-fold higher, 1,313 (888–1,927) ng/ml. The correlation between pre-heparin EL mass and post- heparinELmasswas0.46(p,0.001).ELmassconcentrationsinbothpre-andpost-heparin plasmasignificantlycorrelatedwithallNCEPATPIII-definedmetabolicsyndromefactors:waist circumference(r?0.28and0.22,respectively,p,0.001foreach),bloodpressure(r?0.18and 0.24,p,0.001foreach),