Epidemiology of Concomitant Infection Due to Loa loa and Mansonella perstans in Gabon 英文参考文献.docVIP

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Epidemiology of Concomitant Infection Due to Loa loa and Mansonella perstans in Gabon 英文参考文献.doc

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Epidemiology of Concomitant Infection Due to Loa loa and Mansonella perstans in Gabon 英文参考文献

EpidemiologyofConcomitantInfectionDuetoLoaloa andMansonellaperstansinGabon JeanPaulAkue1*.,Dieudonne′ Nkoghe2,3,4.,CindyPadilla2,GhislainMoussavou2,HubertMoukana1, RogerAntoineMbou1,BenjaminOllomo1,EricMauriceLeroy2,5 1DepartmentofMedicalParasitology,CentreInternationaldeRecherchesMe′dicalesdeFranceville(CIRMF),Franceville,Gabon,2Unite′ desMaladiesViralesEmergentes, CentreInternationaldeRecherchesMe′dicalesdeFranceville,Franceville,Gabon,3MinistryofHealth,Libreville,Gabon,4DepartmentofImmunodeficiencyandInfectious Diseases,UniversityofLiege,Liege,Belgium,5MIVEGEC(IRD224/CNRS5290/UM1/UM2),Montpellier,France Abstract Background:ThefilarialparasitesLoaloaandMansonnellaperstansareendemicinthecentralandwesternAfricanforest block.Loaloaispathogenicandrepresentsamajorobstacletothecontrolofco-endemicfilariaebecauseitstreatmentcan causefatalcomplicationssuchasencephalitis. Methodology/Principal Findings: 4392 individuals aged over 15 years were studied both by direct examination and a concentration technique. The overall prevalence rates were 22.4% for Loa loa microfilaremia, 10.2% for M. perstans microfilaremia, and 3.2% for mixed infection. The prevalence of both filariae was higher in the forest ecosystem than in savannah and lakeland (p,0.0001). The intensity of microfilariae (mf) was also higher in the forest ecosystem for both parasites.Theprevalenceandintensityofmicrofilariawerebothinfluencedbyageandgender.Correlationswerefound betweentheprevalenceandintensityofLoaloamicrofilariae(r=0.215p=0.036),andbetweentheprevalenceofLoaloa and the prevalence of individuals with microfilaria .8000 mf/ml (r=0.624; p,0.0001) and microfilariae .30000 mf/ml (r=0.319,p=0.002).Incontrast,theprevalenceofpruritisandCalabarswellingscorrelatednegativelywiththeprevalence of Loa loa microfilaria (r=20.219, p=0.032; r=20.220; p=0.031, respectively). Pruritis, Calabar swellings and eye worm werenotassociatedwithL.loamfintensity(r=20.144,p=0.162;r–0.061,p=0.558;andr=0.051,p=0.624,respe