Establishing a Successful Bioinformatics Core Facility Team 英文参考文献.docVIP

Perspective EstablishingaSuccessfulBioinformaticsCoreFacility Team FranLewitter1*,MichaelRebhan2* 1BioinformaticsandResearchComputing,WhiteheadInstitute forBiomedicalResearch,Cambridge,Massachusetts, UnitedStates ofAmerica, 2NovartisInstitutes for BioMedicalResearch,Basel,Switzerland Therearemanyissuestoconsiderwhen establishingandbuildingaBioinformatics Core Facility. Mission, funding, scope of at least basic knowledge of statistics and experimental design. In addition to those ‘‘in silico biologists’’, some projects will require people with more extensive back- ground in areas that biologists often cannot cover well, such as data mining and analysis, computer science, structural biologyandbiochemistry,moreadvanced statistics and experimental design, soft- wareengineering,theoreticalbiology,and soon,dependingontheinstitutionandthe mission of the Facility. In such mature Facilities,stayinguptodatewiththemost relevant new approaches becomes attain- able, as different experts can efficiently share ideas taken from the literature and fromscientificmeetings. startingpointofadiscussionthatresultsin solutionsthataddressthemainunderlying problems more effectively), and what can be expected from the Facility (to avoid disappointments due to unrealistic expec- tations, which can be a major problem); and f) communicating the results to the experimentalistinawaythatworksforthe target audience (often requiring many iterationsofanalysesandlabwork). projects, organizational context, infra- structure, software support, and training are among the many to consider. One of themostimportantandarguablythemost critical to success is building the team to execute the mission of the group. We devotethisPerspectivetoourthoughtson thisandrelatedissuesandhowtheyaffect themid-tolong-termsuccessoftheCore Facility, in particular its ability to make strongscientificcontributions. As a measure of the maturity of the Bioinformatics Core Facility, not only will the contributions be value