Epidermal Growth Factor Gene Polymorphism and Risk of Hepatocellular Carcinoma A Meta-Analysis 英文参考文献.docVIP

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Epidermal Growth Factor Gene Polymorphism and Risk of Hepatocellular Carcinoma A Meta-Analysis 英文参考文献.doc

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Epidermal Growth Factor Gene Polymorphism and Risk of Hepatocellular Carcinoma A Meta-Analysis 英文参考文献

EpidermalGrowthFactorGenePolymorphismandRisk ofHepatocellularCarcinoma:AMeta-Analysis Jian-HongZhong1.,Xue-MeiYou1.,Wen-FengGong1.,LiangMa1,YuZhang1,Qin-GuoMo2 ,Liu-Cheng Wu3,JunXiao3,Le-QunLi1* 1HepatobiliarySurgeryDepartment,GuangxiMedicalUniversity,TumorHospital,Nanning,People’sRepublicofChina,2BreastSurgeryDepartment,GuangxiMedical University,TumorHospital,Nanning,People’sRepublicofChina,3GastrointestinalSurgeryDepartment,GuangxiMedicalUniversity,TumorHospital,Nanning,People’s RepublicofChina Abstract Background:Hepatocarcinogenesisisacomplexprocessthatmaybeinfluencedbymanyfactors,includingpolymorphism intheepidermalgrowthfactor(EGF)gene.PreviousworksuggestsanassociationbetweentheEGF61*A/Gpolymorphism (rs4444903) and susceptibility to hepatocellular carcinoma (HCC), but the results have been inconsistent. Therefore, we performedameta-analysisofseveralstudiescoveringalargepopulationtoaddressthiscontroversy. Methods: PubMed, EMBASE, Google Scholar and the Chinese National Knowledge Infrastructure databases were systematicallysearchedtoidentifyrelevantstudies.Datawereabstractedindependentlybytworeviewers.Ameta-analysis wasperformedtoexaminetheassociationbetweenEGF61*A/GpolymorphismandsusceptibilitytoHCC.Oddsratios(ORs) and95%confidenceintervals(95%CIs)werecalculated. Results:Eightstudieswerechoseninthismeta-analysis,involving1,304HCCcases(1135Chinese,44Caucasianand125 mixed)and2,613controls(1638Chinese,77Caucasianand898mixed).TheEGF61*Gallelewassignificantlyassociatedwith increasedriskofHCCbasedonalleliccontrast(OR=1.29,95%CI=1.16–1.44,p,0.001),homozygotecomparison(OR=1.79, 95% CI=1.39–2.29, p,0.001) and a recessive genetic model (OR=1.34, 95% CI=1.16–1.54, p,0.001), while patients carryingtheEGF61*A/AgenotypehadsignificantlylowerriskofHCCthanthosewiththeG/AorG/Ggenotype(A/Avs.G/ A+G/G,OR=0.66,95%CI=0.53–0.83,p,0.001). Conclusion:The61*GpolymorphisminEGFisariskfactorforhepatocarcinogenesiswhiletheEGF61*Aalleleisaprotective factor.Furtherlargeandwell-designedstud