Estimation of Thalamocortical and Intracortical Network Models from Joint Thalamic Single-Electrode and Cortical Laminar-Electrode Recordings in the Rat Barrel System 英文参考文献.docVIP

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Estimation of Thalamocortical and Intracortical Network Models from Joint Thalamic Single-Electrode and Cortical Laminar-Electrode Recordings in the Rat Barrel System 英文参考文献.doc

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Estimation of Thalamocortical and Intracortical Network Models from Joint Thalamic Single-Electrode and Cortical Laminar-Electrode Recordings in the Rat Barrel System 英文参考文献

EstimationofThalamocorticalandIntracorticalNetwork ModelsfromJointThalamicSingle-ElectrodeandCortical Laminar-ElectrodeRecordingsintheRatBarrelSystem PatrickBlomquist1,AnnaDevor2,3,UlfG.Indahl1,IstvanUlbert4,5,GauteT.Einevoll1*,AndersM.Dale3 1DepartmentofMathematicalSciencesandTechnologyandCenterforIntegrativeGenetics,NorwegianUniversityofLifeSciences,As,? Norway,2AthinoulaA.Martinos Center,MassachusettsGeneralHospital,Charlestown,Massachusetts,UnitedStatesofAmerica,3DepartmentsofRadiologyandNeurosciences,UniversityofCalifornia SanDiego,LaJolla,California,UnitedStatesofAmerica,4InstituteforPsychologyoftheHungarianAcademyofSciences,Budapest,Hungary,5PeterPazmanyCatholic University,DepartmentofInformationTechnology,Budapest,Hungary Abstract Anewmethodispresentedforextractionofpopulationfiring-ratemodelsforboththalamocorticalandintracorticalsignal transfer based onstimulus-evoked datafromsimultaneous thalamicsingle-electrode andcortical recordings usinglinear (laminar) multielectrodes in the rat barrel system. Time-dependent population firing rates for granular (layer 4), supragranular (layer 2/3), and infragranular (layer 5) populations in a barrel column and the thalamic population in the homologousbarreloidareextractedfromthehigh-frequencyportion(multi-unitactivity;MUA)oftherecordedextracellular signals. These extracted firing rates are in turn used to identify population firing-rate models formulated as integral equationswithexponentiallydecayingcouplingkernels,allowingforstraightforwardtransformationtothemorecommon firing-rateformulationintermsofdifferentialequations.Optimalmodelstructuresandmodelparametersareidentifiedby minimizing the deviation between model firing rates and the experimentally extracted population firing rates. For the thalamocorticaltransfer,theexperimentaldatafavoramodelwithfastfeedforwardexcitationfromthalamustothelayer-4 laminarpopulationcombinedwithaslowerinhibitoryprocessduetofeedforwardand/orrecurrentconnectionsandmixed linea