Ethnic Differences in Tissue Creatine Kinase Activity An Observational Study 英文参考文献.docVIP

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Ethnic Differences in Tissue Creatine Kinase Activity An Observational Study 英文参考文献.doc

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Ethnic Differences in Tissue Creatine Kinase Activity An Observational Study 英文参考文献

EthnicDifferencesinTissueCreatineKinaseActivity:An ObservationalStudy LizzyM.Brewster1*,CarmenM.D.Coronel2,WillemSluiter3,JosephF.Clark4,GertA.vanMontfrans1 1Departments of Internal and Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, 2Department of Pathology, St. ElisabethHospitaal,Willemstad,Curac?ao,3CenterforLysosomalandMetabolicDiseases,ErasmusMedicalCenter,UniversityofRotterdam,Rotterdam,TheNetherlands, 4VontzCenterforMolecularStudies,UniversityofCincinnati,Cincinnati,Ohio,UnitedStatesofAmerica Abstract Background:Serumcreatinekinase(CK)levelsarereportedtobearound70%higherinhealthyblackpeople,ascompared towhitepeople(medianvalue88IU/Linwhitevs149IU/Linblackpeople).AsserumCKinhealthypeopleisthoughtto occurfromaproportionalleakfromnormaltissues,wehypothesizedthattheblackpopulationsubgrouphasageneralized higherCKactivityintissues. Methodology/Principal Findings: We compared CK activity spectrophotometrically in tissues with high and fluctuating energydemandsincludingcerebrum,cerebellum,heart,renalartery,andskeletalmuscle,obtainedpost-morteminblack and white men. Based on serum values, we conservatively estimated to find a 50% greater CK activity in black people comparedwithwhitepeople,andcalculatedaneedfor10subjectsofonegenderineachgrouptodetectthisdifference. WeusedmixedlinearregressionmodelstoassessthepossibleinfluenceofethnicityonCKactivityindifferenttissues,with ethnicityasafixedcategoricalsubjectfactor,andCKofdifferenttissuesclusteredwithinonepersonastherepeatedeffect responsevariable.Wecollectedpost-mortemtissuesamplesfrom17whiteand10blackmales,meanage62y(SE4).Mean tissueCKactivitywas76%higherintissuesfromblackpeople(estimatedmarginalmeans107.2[95%CI,76.7to137.7]mU/ mgproteininwhite,versus188.6[148.8to228.4]inblackpeople,p =0.002). Conclusion:WefoundevidencethatblackpeoplehavehigherCKactivityinalltissueswithhighandfluctuatingenergy demands studied. This finding may help explain the higher serum CK levels fou