Eukaryotic Cells Producing Ribosomes Deficient in Rpl1 Are Hypersensitive to Defects in the Ubiquitin-Proteasome System 英文参考文献.docVIP

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Eukaryotic Cells Producing Ribosomes Deficient in Rpl1 Are Hypersensitive to Defects in the Ubiquitin-Proteasome System 英文参考文献.doc

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Eukaryotic Cells Producing Ribosomes Deficient in Rpl1 Are Hypersensitive to Defects in the Ubiquitin-Proteasome System 英文参考文献

EukaryoticCellsProducingRibosomesDeficientinRpl1 AreHypersensitivetoDefectsintheUbiquitin- ProteasomeSystem KerriB.McIntosh1,ArpitaBhattacharya1¤,IanM.Willis2,JonathanR.Warner1* 1DepartmentofCellBiology,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica,2DepartmentofBiochemistry,AlbertEinsteinCollegeof Medicine,Bronx,NewYork,UnitedStatesofAmerica Abstract Ithasrecentlybecomeclearthatthemisassemblyofribosomesineukaryoticcellscanhavedeleteriouseffectsthatgofar beyondasimpleshortageofribosomes.InthisworkwefindthatcellsdeficientinribosomalproteinL1(Rpl1;Rpl10ain mammals) produce ribosomes lacking Rpl1 that are exported to the cytoplasm and that can be incorporated into polyribosomes. The presence of such defective ribosomes leads to slow growth and appears to render the cells hypersensitive to lesions in the ubiquitin-proteasome system. Several genes that were reasonable candidates for degradationof60SsubunitslackingRpl1failtodoso,suggestingthatkeyplayersinthesurveillanceofribosomalsubunits remaintobefound.Interestingly,inspiteofrenderingthecellshypersensitivetotheproteasomeinhibitorMG132,shortage ofRpl1partiallysuppressesthestress-invokedtemporaryrepressionofribosomesynthesiscausedbyMG132. Citation:McIntoshKB,BhattacharyaA,WillisIM,WarnerJR(2011)EukaryoticCellsProducingRibosomesDeficientinRpl1AreHypersensitivetoDefectsinthe Ubiquitin-ProteasomeSystem.PLoSONE6(8):e23579.doi:10.1371/journal.pone.0023579 Editor:StevenR.Ellis,UniversityofLouisville,UnitedStatesofAmerica ReceivedJune23,2011;AcceptedJuly20,2011;PublishedAugust12,2011 Copyright: ? 2011 McIntosh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisresearchwassupportedinpartbygrantsfromtheNationalInstitutesofHealth:GM25532andARRAGM25532-S1toJRW,GM085177toIMW,and CAI-3330totheAlbertEinsteinCancerCenter.KBMwast