Evaluation of Protective Efficacy of Respiratory Syncytial Virus Vaccine against A and B Subgroup Human Isolates in Korea 英文参考文献.docVIP

下载本文档

2
0
约 9页
2017-05-11 发布于上海
举报
版权申诉

Evaluation of Protective Efficacy of Respiratory Syncytial Virus Vaccine against A and B Subgroup Human Isolates in Korea 英文参考文献.doc

1、本文档共9页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Evaluation of Protective Efficacy of Respiratory Syncytial Virus Vaccine against A and B Subgroup Human Isolates in Korea 英文参考文献

EvaluationofProtectiveEfficacyofRespiratorySyncytial VirusVaccineagainstAandBSubgroupHumanIsolates inKorea Ji-EunJang1,Jee-BoongLee1,Kyung-HyoKim2,SungMooPark3,Byoung-ShikShim3,InSooCheon3, ManKiSong3,JunChang1* 1DivisionofLifeandPharmaceuticalSciences,CenterforCellSignalingandDrugDiscoveryResearch,EwhaWomansUniversity,Seoul,Korea,2DepartmentofPediatrics, CenterforVaccineEvaluationandStudy,EwhaWomansUniversitySchoolofMedicine,Seoul,Korea,3LaboratoryScienceDivision,InternationalVaccineInstitute,Seoul, Korea Abstract Humanrespiratorysyncytialvirus(HRSV)isasignificantcauseofupperandlowerrespiratorytractillnessmainlyininfants and young children worldwide. HRSV is divided into two subgroups, HRSV-A and HRSV-B, based on sequence variation within the Ggene. Despite its importance asa respiratory pathogen, thereis currently no safe andeffective vaccine for HRSV.Inthisstudy,wehavedetectedandidentifiedtheHRSVbyRT-PCRfromnasopharyngealaspiratesofKoreanpediatric patients.Interestingly,allHRSV-Bisolatesexhibiteduniquedeletionof6nucleotidesandduplicationof60nucleotidesin theGgene.Wesuccessfullyamplifiedtwoisolates(‘KR/A/09-8’belongingtoHRSV-Aand‘KR/B/10-12’toHRSV-B)onlarge- scale,andevaluatedthecross-protectiveefficacyofourrecombinantadenovirus-basedHRSVvaccinecandidate,rAd/3xG, by challenging the immunized mice with these isolates. The single intranasal immunization with rAd/3xG protected the mice completely from KR/A/09-8 infection and partially from KR/B/10-12 infection. Our study contributes to the understandingofthegeneticcharacteristicsanddistributionofsubgroupsintheseasonalHRSVepidemicsinKoreaand,for thefirsttime,totheevaluationofthecross-protectiveefficacyofRSVvaccineagainstHRSV-Aand-Bfield-isolates. Citation: Jang J-E, Lee J-B, Kim K-H, Park SM, Shim B-S, et al. (2011) Evaluation of Protective Efficacy of Respiratory Syncytial Virus Vaccine against A and B SubgroupHumanIsolatesinKorea.PLoSONE6(9):e23797.doi:10.1371/journal.pone.0023797 Editor:RalphTripp,UniversityofGeor