Evidence of Molecular Evolution Driven by Recombination Events Influencing Tropism in a Novel Human Adenovirus that Causes Epidemic Keratoconjunctivitis 英文参考文献.docVIP
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Evidence of Molecular Evolution Driven by Recombination Events Influencing Tropism in a Novel Human Adenovirus that Causes Epidemic Keratoconjunctivitis 英文参考文献
EvidenceofMolecularEvolutionDrivenby
RecombinationEventsInfluencingTropisminaNovel
HumanAdenovirusthatCausesEpidemic
Keratoconjunctivitis
MichaelP.Walsh1,AshishChintakuntlawar2,ChristopherM.Robinson2,IjadMadisch3,Bala′zsHarrach4,
NolanR.Hudson5,DavidSchnurr6,AlbertHeim3,JamesChodosh2,DonaldSeto1,MorrisS.Jones5*
1DepartmentofBioinformaticsandComputationalBiology,GeorgeMasonUniversity,Manassas,Virginia,UnitedStatesofAmerica,2HoweLaboratory,Massachusetts
EyeandEarInfirmary,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica, 3Insitutfu¨rVirologie,MedizinischeHochschule,Hannover,Germany,
4VeterinaryMedicalResearchInstitute,HungarianAcademyofSciences,Budapest,Hungary,5ClinicalInvestigationFacility,DavidGrantUSAFMedicalCenter,TravisAFB,
California,UnitedStatesofAmerica,6ViralandRickettsialDiseaseLaboratory,CaliforniaDepartmentofPublicHealth,Richmond,California,UnitedStatesofAmerica
Abstract
In2005,ahumanadenovirusstrain(formerlyknownasHAdV-D22/H8butrenamedhereHAdV-D53)wasisolatedfroman
outbreakofepidemickeratoconjunctititis(EKC),adiseasethatisusuallycausedbyHAdV-D8,-D19,or-D37,notHAdV-D22.
To date, a complete change of tropism compared to the prototype has never been observed, although apparent
recombinant strains of other viruses from species Human adenovirus D (HAdV-D) have been described. The complete
genomeofHAdV-D53wassequencedtoelucidaterecombinationeventsthatleadtotheemergenceofaviableandhighly
virulent virus with a modified tropism. Bioinformatic and phylogenetic analyses of this genome demonstrate that this
adenovirus is a recombinant of HAdV-D8 (including the fiber gene encoding the primary cellular receptor binding site),
HAdV-D22,(the edeterminant of thehexongene), HAdV-D37(including thepenton basegeneencoding thesecondary
cellular receptor binding site), and at least one unknown or unsequenced HAdV-D strain. Bootscanning analysis of the
complete genomic sequence of this novel adenovirus, which we have re-named HAdV-D53, indicated at leas
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