Evolutionary Adaptation of the Amino Acid and Codon Usage of the Mosquito Sodium Channel following Insecticide Selection in the Field Mosquitoes 英文参考文献.docVIP

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Evolutionary Adaptation of the Amino Acid and Codon Usage of the Mosquito Sodium Channel following Insecticide Selection in the Field Mosquitoes 英文参考文献.doc

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Evolutionary Adaptation of the Amino Acid and Codon Usage of the Mosquito Sodium Channel following Insecticide Selection in the Field Mosquitoes 英文参考文献

EvolutionaryAdaptationoftheAminoAcidandCodon UsageoftheMosquitoSodiumChannelfollowing InsecticideSelectionintheFieldMosquitoes QiangXu1¤a,LeeZhang2,TingLi1,LanZhang1¤b,LinHe1¤c,KeDong3,NannanLiu1* 1DepartmentofEntomologyandPlantPathology,AuburnUniversity,Auburn,Alabama,UnitedStatesofAmerica,2GenomicsLaboratory,AuburnUniversity,Auburn, Alabama,UnitedStatesofAmerica,3DepartmentofEntomology,MichiganStateUniversity,EastLansing,Michigan,UnitedStatesofAmerica Abstract Target site insensitivity resulting from point mutations within the voltage-gated sodium channel of the insect nervous systemisknowntobeofprimaryimportanceinthedevelopmentofresistancetopyrethroidinsecticides.Thisstudyshifts currentresearchparadigmsbyconducting,forthefirsttime,aglobalanalysisofallthenaturallyoccurringmutations,both nonsynonymousandsynonymousmutations,aswellasmutationcombinationsintheentiremosquitosodiumchannelof Culexquinquefasciatusandanalyzingtheirevolutionaryandheritablefeatureandrolesininsecticideresistance.Througha systematicanalysisofcomparingnucleotidepolymorphisms intheentiresodiumchannelcDNAsofindividualsbetween susceptibleandresistantmosquitostrains,betweenfieldparentalmosquitoesandtheirpermethrinselectedoffspring,and amongdifferentmosquitogroupscategorizedbytheirlevelsoftolerancetospecificpermethrinconcentrationswithinand amongthemosquitostrainsofthefieldparentalstrainsandtheirpermethrinselectedoffspring,3nonsynonymous(A109S, L982F,andW1573R)and6synonymous(L852,G891,A1241,D1245,P1249,andG1733)mutationswereidentified.Theco-existence ofall9mutations,bothnonsynonymousandsynonymous,andtheirhomozygousitywerefoundtobeimportantfactorsfor high levels of resistance. Our study, for the first time, provide a strong case demonstrating the co-existence of both nonsynonymous and synonymous mutations in the sodium channel of resistant mosquitoes in response to insecticide resistanceandtheinheritanceofthesemutationsintheoffspringoffieldmosquitostrainsfollowinginsecticideselection. Citation:XuQ