Evolutionary Plasticity and Innovations in Complex Metabolic Reaction Networks 英文参考文献.docVIP

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Evolutionary Plasticity and Innovations in Complex Metabolic Reaction Networks 英文参考文献.doc

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Evolutionary Plasticity and Innovations in Complex Metabolic Reaction Networks 英文参考文献

EvolutionaryPlasticityandInnovationsinComplex MetabolicReactionNetworks Joa?oF.MatiasRodrigues1,3*,AndreasWagner1,2,3 1DepartmentofBiochemistry,UniversityofZu¨rich,Zu¨rich,Switzerland,2TheSantaFeInstitute,SantaFe,NewMexico,UnitedStatesofAmerica,3TheSwissInstituteof Bioinformatics,Zu¨rich,Switzerland Abstract Genome-scalemetabolicnetworksarehighlyrobusttotheeliminationofenzyme-codinggenes.Theirstructurecanevolve rapidlythroughmutationsthateliminatesuchgenesandthroughhorizontalgenetransferthataddsnewenzyme-coding genes. Using flux balance analysis we study a vast space of metabolic network genotypes and their relationship to metabolicphenotypes,theabilitytosustainlifeinanenvironmentdefinedbyanavailablespectrumofcarbonsources.Two such networks typically differ in most of their reactions and have few essential reactions in common. Our observations suggestthattherobustnessoftheEscherichia colimetabolicnetworktomutationsistypicalofnetworkswiththesame phenotype.Wealsodemonstratethatnetworkswiththesamephenotypeformlargesetsthatcanbetraversedthrough singlemutations,andthatsinglemutationsofdifferentgenotypeswiththesamephenotypecanyieldverydifferentnovel phenotypes.Thismeansthattheevolutionaryplasticityandrobustnessofmetabolicnetworksfacilitatestheevolutionof new metabolic abilities. Our approach has broad implications for the evolution of metabolic networks, for our understandingofmutationalrobustness,forthedesignofantimetabolicdrugs,andformetabolicengineering. Citation: Matias Rodrigues JF, Wagner A (2009) Evolutionary Plasticity and Innovations in Complex Metabolic Reaction Networks. PLoS Comput Biol 5(12): e1000613.doi:10.1371/journal.pcbi.1000613 Editor:NathanD.Price,UniversityofIllinoisatUrbana-Champaign,UnitedStatesofAmerica ReceivedJune29,2009;AcceptedNovember16,2009;PublishedDecember18,2009 Copyright:?2009MatiasRodrigues,Wagner.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,which permitsunrestricteduse,distribution,andre