Expression and Localization of CLC Chloride Transport Proteins in the Avian Retina 英文参考文献.docVIP

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Expression and Localization of CLC Chloride Transport Proteins in the Avian Retina 英文参考文献.doc

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Expression and Localization of CLC Chloride Transport Proteins in the Avian Retina 英文参考文献

ExpressionandLocalizationofCLCChlorideTransport ProteinsintheAvianRetina EmilyMcMains,VijaiKrishnan,SujithaPrasad,EvannaGleason* DepartmentofBiologicalSciences,LouisianaStateUniversity,BatonRouge,Louisiana,UnitedStatesofAmerica Abstract MembersoftheubiquitouslyexpressedCLCproteinfamilyofchloridechannelsandtransportersplayimportantrolesin + regulatingcellularchlorideandpH.TheCLCsthatfunctionasCl2/H antiporters,ClCs3–7,areessentialinparticularforthe acidificationofendosomalcompartmentsandproteindegradation.Theseproteinsarebroadly expressedinthenervous system,andmutationsthatdisrupttheirexpressionareresponsibleforseveralhumangeneticdiseases.Furthermore,knock- outofClC3andClC7inthemouseresultinthedegenerationofthehippocampusandtheretina.Despitethisevidenceof theirimportanceinretinalfunction,theexpressionpatternsofdifferentCLCtransportersindifferentretinalcelltypesareas yet undescribed. Previous work in our lab has shown that in chicken amacrine cells, internal Cl2 can be dynamic. To determinewhetherCLCshavethepotentialtoparticipate,weusedPCRandimmunohistochemicaltechniquestoexamine CLCtransporterexpressioninthechickenretina.Weobservedahighlevelofvariationintheretinalexpressionlevelsand patternsamongthedifferentCLCproteinsexamined.Thesefindings,whichrepresentthefirstsystematicinvestigationof CLCtransporterexpressionintheretina,supportdiversefunctionsforthedifferentCLCsinthistissue. Citation:McMainsE,KrishnanV,PrasadS,GleasonE(2011)ExpressionandLocalizationofCLCChlorideTransportProteinsintheAvianRetina.PLoSONE6(3): e17647.doi:10.1371/journal.pone.0017647 Editor:DamienKeating,FlindersUniversity,Australia ReceivedNovember3,2010;AcceptedFebruary6,2011;PublishedMarch7,2011 Copyright: ? 2011 McMains et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbytheNationalEy