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Exercise Increases Serum Fibroblast Growth Factor 21 (FGF21) Levels 英文参考文献
ExerciseIncreasesSerumFibroblastGrowthFactor21
(FGF21)Levels
DanielCuevas-Ramos1,PalomaAlmeda-Valde′s1,ClaraElenaMeza-Arana2,GriseldaBrito-Co′rdova1,
FranciscoJ.Go′mez-Pe′rez1,RoopaMehta1,JorgeOseguera-Moguel3,CarlosA.Aguilar-Salinas1*
1Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Department of Internal
Medicine,InstitutoNacionaldeCienciasMedicasyNutricionSalvadorZubiran,MexicoCity,Mexico,3DeparmentofCardiology,InstitutoNacionaldeCienciasMedicasy
NutricionSalvadorZubiran,MexicoCity,Mexico
Abstract
Background:Fibroblastgrowthfactor21(FGF21)increasesglucoseuptake.ItisunknownifFGF21serumlevelsareaffected
byexercise.
Methodology/PrincipalFindings:Thiswasacomparativelongitudinalstudy.Anthropometricandbiochemicalevaluation
werecarriedoutbeforeandafteraboutofexerciseandrepeatedaftertwoweeksofdailysupervisedexercise.Thestudy
samplewascomposedof60sedentaryyounghealthywomen.Themeanagewas2463.7yearsold,andthemeanBMIwas
21.467.0kg/m2.Theanthropometriccharacteristicsdidnotchangeaftertwoweeksofexercise.FGF21levelssignificantly
increasedaftertwoweeksofexercise(276.8ng/l(142.8–568.6)vs.(460.8(298.2–742.1),p,0.0001)).Thedelta(final–basal)
logofserumFGF21,adjustedforBMI,showedasignificantpositivecorrelationwithbasalglucose(r=0.23,p=0.04),mean
maximalheartrate(MHR)(r=0.54,p,0.0001),meanMETs(r=0.40,p=0.002),deltaplasmaepinephrine(r=0.53,p,0.0001)
anddeltaplasmaFFAs(r=0.35,p=0.006).Astepwiselinearregressionmodelshowedthatglucose,MHR,METs,FFAs,and
epinephrine, were factors independently associated with the increment in FGF21 after the exercise program (F=4.32;
r2=0.64,p,0.0001).
Conclusions: Serum FGF21 levels significantly increased after two weeks of physical activity. This increment correlated
positivelywithclinicalparametersrelatedtotheadrenergicandlipolyticresponsetoexercise.
TrialRegistration:ClinicalTNCCitation:Cuevas-RamosD,Almeda-Valde′sP,Meza-AranaCE,Brito-Co′rdovaG,Go′mez-Pe′r
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