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Exercise Increases Serum Fibroblast Growth Factor 21 (FGF21) Levels 英文参考文献.docVIP

Exercise Increases Serum Fibroblast Growth Factor 21 (FGF21) Levels 英文参考文献.doc

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Exercise Increases Serum Fibroblast Growth Factor 21 (FGF21) Levels 英文参考文献

ExerciseIncreasesSerumFibroblastGrowthFactor21 (FGF21)Levels DanielCuevas-Ramos1,PalomaAlmeda-Valde′s1,ClaraElenaMeza-Arana2,GriseldaBrito-Co′rdova1, FranciscoJ.Go′mez-Pe′rez1,RoopaMehta1,JorgeOseguera-Moguel3,CarlosA.Aguilar-Salinas1* 1Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Department of Internal Medicine,InstitutoNacionaldeCienciasMedicasyNutricionSalvadorZubiran,MexicoCity,Mexico,3DeparmentofCardiology,InstitutoNacionaldeCienciasMedicasy NutricionSalvadorZubiran,MexicoCity,Mexico Abstract Background:Fibroblastgrowthfactor21(FGF21)increasesglucoseuptake.ItisunknownifFGF21serumlevelsareaffected byexercise. Methodology/PrincipalFindings:Thiswasacomparativelongitudinalstudy.Anthropometricandbiochemicalevaluation werecarriedoutbeforeandafteraboutofexerciseandrepeatedaftertwoweeksofdailysupervisedexercise.Thestudy samplewascomposedof60sedentaryyounghealthywomen.Themeanagewas2463.7yearsold,andthemeanBMIwas 21.467.0kg/m2.Theanthropometriccharacteristicsdidnotchangeaftertwoweeksofexercise.FGF21levelssignificantly increasedaftertwoweeksofexercise(276.8ng/l(142.8–568.6)vs.(460.8(298.2–742.1),p,0.0001)).Thedelta(final–basal) logofserumFGF21,adjustedforBMI,showedasignificantpositivecorrelationwithbasalglucose(r=0.23,p=0.04),mean maximalheartrate(MHR)(r=0.54,p,0.0001),meanMETs(r=0.40,p=0.002),deltaplasmaepinephrine(r=0.53,p,0.0001) anddeltaplasmaFFAs(r=0.35,p=0.006).Astepwiselinearregressionmodelshowedthatglucose,MHR,METs,FFAs,and epinephrine, were factors independently associated with the increment in FGF21 after the exercise program (F=4.32; r2=0.64,p,0.0001). Conclusions: Serum FGF21 levels significantly increased after two weeks of physical activity. This increment correlated positivelywithclinicalparametersrelatedtotheadrenergicandlipolyticresponsetoexercise. TrialRegistration:ClinicalTNCCitation:Cuevas-RamosD,Almeda-Valde′sP,Meza-AranaCE,Brito-Co′rdovaG,Go′mez-Pe′r

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