Fatty Liver Index Predicts Further Metabolic Deteriorations in Women with Previous Gestational Diabetes 英文参考文献.docVIP

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Fatty Liver Index Predicts Further Metabolic Deteriorations in Women with Previous Gestational Diabetes 英文参考文献.doc

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Fatty Liver Index Predicts Further Metabolic Deteriorations in Women with Previous Gestational Diabetes 英文参考文献

FattyLiverIndexPredictsFurtherMetabolic DeteriorationsinWomenwithPreviousGestational Diabetes LatifeBozkurt1,ChristianS.Go¨bl1,2,AndreaTura3,MarekChmelik4,ThomasPrikoszovich1,LanaKosi1, OswaldWagner5,MichaelRoden6,GiovanniPacini3,AmaliaGastaldelli7,AlexandraKautzky-Willer1* 1UnitofGenderMedicine,DivisionofEndocrinologyandMetabolism,DepartmentofInternalMedicineIII,MedicalUniversityofVienna,Vienna,Austria,2Divisionof Feto-MaternalMedicine,DepartmentofGyneacologyandObstetrics,MedicalUniversityofVienna,Vienna,Austria,3MetabolicUnit,InstituteofBiomedicalEngineering, National Research Council, Padova, Italy, 4High Field Magnetic Resonance Centre of Excellence, Medical University of Vienna, Vienna, Austria, 5Chemical Laboratory Diagnostics,ClinicalInstituteforMedical,MedicalUniversityofVienna,Vienna,Austria,6DepartmentofMetabolicDiseases,GermanDiabetesCenter,LeibnizCenterfor DiabetesResearch,InstituteforClinicalDiabetology,Heinrich-HeineUniversity,Du¨sseldorf,Germany,7CardiometabolicRiskUnit,InstituteofClinicalPhysiology,National ResearchCouncil,Pisa,Italy Abstract BackgroundandAims:Determinantsoffattyliver(FL)mightbepredictiveforfurtherdeteriorationininsulinresistance(IR) in women with previous gestational diabetes (pGDM). The aim was to evaluate the association between pGDM, FL and futuremanifestationoftype2diabetes(T2DM)byadetailedpathophysiologicalcharacterizationearlyafterpregnancy. Methods: 68 pGDM and29healthy controls wereincluded 3–6monthsafter delivery andunderwent specificmetabolic assessments:statusofIRwasdeterminedviaoral-andintravenous-glucose-tolerance-testswithanalysisofproinflammatory factors and kinetics of free-fatty-acids (FFA). According to the fatty-liver-index (FLI), pGDMs were categorized into three groups with low (FLI#20), intermediate (20,FLI,60) and high (FLI$60) risk for FL to assess differences in metabolic parameters at baseline as well as in the 10-year incidence for T2DM. Accuracy of FLI was proven with 1H-magnetic- resonance-spectroscopy