Feature Selection and Classification of MAQC-II Breast Cancer and Multiple Myeloma Microarray Gene Expression Data 英文参考文献.docVIP

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Feature Selection and Classification of MAQC-II Breast Cancer and Multiple Myeloma Microarray Gene Expression Data 英文参考文献.doc

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Feature Selection and Classification of MAQC-II Breast Cancer and Multiple Myeloma Microarray Gene Expression Data 英文参考文献

FeatureSelectionandClassificationofMAQC-IIBreast CancerandMultipleMyelomaMicroarrayGene ExpressionData QingzhongLiu1,AndrewH.Sung1*,ZhongxueChen2,JianzhongLiu3,XudongHuang4 ,Youping Deng5,6 * 1DepartmentofComputerScienceandInstituteforComplexAdditiveSystemsAnalysis,NewMexicoTech,Socorro,NewMexico,UnitedStatesofAmerica,2Department of Epidemiology Biostatistics, Robert Stempel College of Public Health Social Work, Florida International University, Miami, Florida, United States of America, 3QuantumBio Inc., State College, Pennsylvania, United States of America, 4Division of Nuclear Medicine and Molecular Imaging and Center for Advanced Medical Imaging,DepartmentofRadiology,BrighamandWomen’sHospitalandHarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,5SpecPro,Vicksburg, Mississippi,UnitedStatesofAmerica,6DepartmentofBiologyScience,theUniversityofSouthernMississippi,Hattiesburg,Mississippi,UnitedStatesofAmerica Abstract Microarray data has a high dimension of variables but available datasets usually have only a small number of samples, thereby making the study of such datasets interesting and challenging. In the task of analyzing microarray data for the purposeof,e.g.,predictinggene-diseaseassociation,featureselectionisveryimportantbecauseitprovidesawaytohandle thehighdimensionalitybyexploitinginformationredundancyinducedbyassociationsamonggeneticmarkers.Judicious featureselectioninmicroarraydataanalysiscanresultinsignificantreductionofcostwhilemaintainingorimprovingthe classification or prediction accuracy of learning machines that are employed to sort out the datasets. In this paper, we propose a gene selection method called Recursive Feature Addition (RFA), which combines supervised learning and statisticalsimilaritymeasures.Wecompareourmethodwiththefollowinggeneselectionmethods: N SupportVectorMachineRecursiveFeatureElimination(SVMRFE) N Leave-One-OutCalculationSequentialForwardSelection(LOOCSFS) N GradientbasedLeave-one-outGeneSelection(GLGS) To