Extracting Multiscale Pattern Information of fMRI Based Functional Brain Connectivity with Application on Classification of Autism Spectrum Disorders 英文参考文献.docVIP

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Extracting Multiscale Pattern Information of fMRI Based Functional Brain Connectivity with Application on Classification of Autism Spectrum Disorders 英文参考文献.doc

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Extracting Multiscale Pattern Information of fMRI Based Functional Brain Connectivity with Application on Classification of Autism Spectrum Disorders 英文参考文献

ExtractingMultiscalePatternInformationoffMRIBased FunctionalBrainConnectivitywithApplicationon ClassificationofAutismSpectrumDisorders HuiWang,ChenChen,HsiehFushing* DepartmentofStatistics,UniversityofCaliforniaDavis,Davis,California,UnitedStatesofAmerica Abstract We employed a multi-scale clustering methodology known as ‘‘data cloud geometry’’ to extract functional connectivity patterns derived from functional magnetic resonance imaging (fMRI) protocol. The method was applied to correlation matricesof106regionsofinterest(ROIs)in29individualswithautismspectrumdisorders(ASD),and29individualswith typicaldevelopment(TD)whiletheycompletedacognitivecontroltask.Connectivityclusteringgeometrywasexaminedat both‘‘fine’’and‘‘coarse’’scales.Atthecoarsescale,theconnectivityclusteringgeometryproduced10validclusterswitha coherentrelationshiptoneuralanatomy.Asupervisedlearningalgorithmemployedfinescaleinformationaboutclustering motif configurations and prevalence, and coarse scale information about intra- and inter-regional connectivity; the algorithm correctly classified ASD and TD participants with sensitivity of 82:8% and specificity of 82:8%. Most of the predictivepowerofthelogisticregressionmodelresidedatthelevelofthefine-scaleclusteringgeometry,suggestingthat cellularversussystemsleveldisturbancesaremoreprominentinindividualswithASD.Thisarticleprovidesvalidationfor this multi-scale geometric approach to extracting brain functional connectivity pattern information and for its use in classificationofASD. Citation: Wang H, Chen C, Fushing H (2012) Extracting Multiscale Pattern Information of fMRI Based Functional Brain Connectivity with Application on ClassificationofAutismSpectrumDisorders.PLoSONE7(10):e45502.doi:10.1371/journal.pone.0045502 Editor:SatoruHayasaka,WakeForestSchoolofMedicine,UnitedStatesofAmerica ReceivedFebruary13,2012;AcceptedAugust20,2012;PublishedOctober8,2012 Copyright: ? 2012 Wang et al. This is an open-access article distributed under the terms of the C