First Report of Sylvatic DENV-2-Associated Dengue Hemorrhagic Fever in West Africa 英文参考文献.docVIP

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First Report of Sylvatic DENV-2-Associated Dengue Hemorrhagic Fever in West Africa 英文参考文献.doc

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First Report of Sylvatic DENV-2-Associated Dengue Hemorrhagic Fever in West Africa 英文参考文献

FirstReportofSylvaticDENV-2-AssociatedDengue HemorrhagicFeverinWestAfrica LeticiaFranco1*.,GustavoPalacios2.,Jose′ AntonioMartinez3,AnaVa′zquez1,NazirSavji2,FernandoDe Ory1,Mar?′aPazSanchez-Seco1,DoloresMart?′n4,W.IanLipkin2,AntonioTenorio1 1National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain, 2Center for Infection and Immunity, Mailman School of Public Health, ColumbiaUniversity,NewYork,NewYork,UnitedStatesofAmerica,3HospitalInfantaCristina,Parla,Madrid,Spain,4LaboratorioBrSalud,SanSebastia′n delosReyes, Madrid,Spain Abstract Denguevirus(DENV)circulatesinhumanandsylvaticcycles.Sylvaticstrainsarebothecologicallyandevolutionarilydistinct fromendemicviruses.AlthoughsylvaticdenguecyclesoccurinWestAfricancountriesandMalaysia,onlyafewcasesof mild human disease caused by sylvatic strains and one single case of dengue hemorrhagic fever in Malaysia have been reported.Herewereportacaseofdenguehemorrhagicfever(DHF)withthrombocytopenia(13000/ml),araisedhematocrit (32%abovebaseline)andmucosalbleedingina27-year-oldmalereturningtoSpaininNovember2009aftervisitinghis homecountryGuineaBissau.SylvaticDENV-2WestAfricanlineagewasisolatedfrombloodandsera.Thisisthefirstcaseof DHFassociatedwithsylvaticDENV-2inAfricaandthesecondcaseworldwideofDHFcausedbyasylvaticstrain. Citation: Franco L, Palacios G, Martinez JA, Va′zquez A, Savji N, et al. (2011) First Report of Sylvatic DENV-2-Associated Dengue Hemorrhagic Fever in West Africa.PLoSNeglTropDis5(8):e1251.doi:10.1371/journal.pntd.0001251 Editor:AnnM.Powers,CentersforDiseaseControlandPrevention,UnitedStatesofAmerica ReceivedFebruary11,2011;AcceptedJune9,2011;PublishedAugust2,2011 Copyright: ? 2011 Franco et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:FinancialsupportwasprovidedbytheFondodeInvestigacion