Genome-Wide Scan Identifies Variant in TNFSF13 Associated with Serum IgM in a Healthy Chinese Male Population 英文参考文献.docVIP
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Genome-Wide Scan Identifies Variant in TNFSF13 Associated with Serum IgM in a Healthy Chinese Male Population 英文参考文献
Genome-WideScanIdentifiesVariantinTNFSF13
AssociatedwithSerumIgMinaHealthyChineseMale
Population
MingYang1.,YongmingWu1,3.,YanmeiLu1.,ChangyuanLiu1.,JielinSun2,MingLiao1,3,MinQin1,
LinjianMo1,3,YongGao1,3,ZhengLu1,3,ChunleiWu1,3,YoujieZhang1,3,HaiyingZhang1,4,XueQin1,5
YanlingHu1,6,ShijunZhang1,7,JianlingLi1,8,MinDong1,S.LillyZheng2,JianfengXu2,9,10,11,
,
XiaoboYang1,4*,AihuaTan1,12*,ZengnanMo1,3
*
1CenterforGenomicandPersonalizedMedicine,TheFirstAffiliatedHospitalofGuangxiMedicalUniversity,Nanning,Guangxi,People’sRepublicofChina,2Centerfor
CancerGenomics,WakeForestUniversitySchoolofMedicine,Winston-Salem,NorthCarolina,UnitedStatesofAmerica,3InstituteofUrologyandNephrology,theFirst
AffiliatedHospitalofGuangxiMedicalUniversity,Nanning,Guangxi,People’sRepublicofChina,4DepartmentofOccupationalHealthandEnvironmentalHealth,Guangxi
MedicalUniversity,Nanning,Guangxi,People’sRepublicofChina,5DepartmentofClinicalLaboratory,theFirstAffiliatedHospitalofGuangxiMedicalUniversity,Nanning,
Guangxi,People’sRepublicofChina,6MedicalScientificResearchCenter,GuangxiMedicalUniversity,Nanning,Guangxi,People’sRepublicofChina,7Departmentof
Pharmacology,GuangxiMedicalUniversity,Nanning,Guangxi,People’sRepublicofChina,8InstituteofCardiovascularDisease,theFirstAffiliatedHospitalofGuangxi
MedicalUniversity,Nanning,Guangxi,People’sRepublicofChina,9CenterforGeneticEpidemiology,VanAndelResearchInstitute,GrandRapids,Michigan,UnitedStates
ofAmerica,10Fudan-VARICenterforGeneticEpidemiology,FudanUniversity,Shanghai,People’sRepublicofChina,11FudanUniversityInstituteofUrology,Huashan
Hospital,Shanghai,People’sRepublicofChina,12DepartmentofChemotherapy,theAffiliatedTumorHospitalofGuangxiMedicalUniversity,Nanning,Guangxi,People’s
RepublicofChina
Abstract
IgMprovidesafirstlineofdefenseduringmicrobialinfections.SerumIgMlevelsaredetectedroutinelyinclinicalpractice.
And IgM is a genetically complex trait. We conducted a two-stage genome-wide association study (GWAS) to identify
geneticvariantsaffectingseru
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