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Grading Quality of Evidence and Strength of Recommendations A Perspective 英文参考文献
Perspective
GradingQualityofEvidenceandStrengthof
Recommendations:APerspective
MohammedT.Ansari1*,AlexanderTsertsvadze1,DavidMoher1,2
1OttawaMethodsCentre,ClinicalEpidemiologyProgram,OttawaHospitalResearchInstitute,Ottawa,Canada,2DepartmentofEpidemiologyCommunityMedicine,
FacultyofMedicine,UniversityofOttawa,Ottawa,Canada
Evidence-based practice requires trans-
lating research findings into clinical and
policy decision making. Clinical practice
guidelines (CPGs) serve this purpose by
evaluating evidence and making recom-
mendations about therapeutic and diag-
nostic interventions and clinical manage-
ment strategies. Systematic reviews are
consideredthebestavailableevidenceand
are often used in the development of
CPGs [1,2]. Since guideline development
involves an assessment of the overall
qualityofevidenceandcomplexbalancing
of trade-offs between the important ben-
efitsandharmsofanygivenintervention,
arbitrariness, value judgements, and sub-
jectivity ultimately come into play in the
guidelinedevelopmentprocessandassoci-
ated recommendations [3]. In order to
minimize cognitive bias in interpreting
evidenceand maketheinherentlysubjec-
tive process more transparent and consis-
tent, CPGs have traditionally employed
formal systems or frameworks to under-
standandgradethequalityofthebodyof
evidence and strength of recommenda-
tions[4,5].
evidence, we would have concurred with
someofKavanagh’scriticismofGRADE.
However,weseeGRADEasaframework
uncoveringimplicitsubjectivityandinvok-
ing a systematic, explicit, judicious, and
transparent approach to interpreting, as
opposedto‘‘capturing’’evidence.Itreveals
howvaluesareassignedtojudgments,but
whatvaluesareassigneditdoesnotdictate
simplybecauseitcannotdictate.Belowwe
firstpresentourconcernaboutoneaspectof
the GRADE framework and then our
perspectiveonthevariouscriticismsofit.
LinkedResearchArticle
This Perspective discusses the fol-
lowingnewPolicyForumpublished
inPLoSMedicine:
Kavanagh B (2009) The GRADE
System for Ra
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