High Levels of Aromatic Amino Acids in Gastric Juice during the Early Stages of Gastric Cancer Progression 英文参考文献.docVIP

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High Levels of Aromatic Amino Acids in Gastric Juice during the Early Stages of Gastric Cancer Progression 英文参考文献.doc

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High Levels of Aromatic Amino Acids in Gastric Juice during the Early Stages of Gastric Cancer Progression 英文参考文献

HighLevelsofAromaticAminoAcidsinGastricJuice duringtheEarlyStagesofGastricCancerProgression KaiDeng,SanrenLin,LiyaZhou*,YuanLi,MoChen,YingchunWang,YuwenLi DepartmentofGastroenterology,PekingUniversityThirdHospital,Beijing,China Abstract Background: Early-stage gastric cancer is mostly asymptomatic and can easily be missed easily by conventional gastroscopy.Currently,therearenousefulbiomarkersfortheearlydetectionofgastriccancer,andtheiridentificationof biomarkersisurgentlyneeded. Methods:Gastricjuicewasobtainedfrom185subjectsthatweredividedintothreegroups:non-neoplasticgastricdisease (NGD),advancedgastriccancerandearlygastriccancer(EGC).Thelevelsofaromaticaminoacidsinthegastricjuicewere quantitatedusinghigh-performanceliquidchromatography. Results:Themedianvalues(25thto75thpercentile)oftyrosine,phenylalanineandtryptophaninthegastricjuicewere3.8 (1.7–7.5)mg/ml,5.3(2.3–9.9)mg/mland1.0(0.4–2.8)mg/mlinNGD;19.4(5.8–72.4)mg/ml,24.6(11.5–73.7)mg/mland8.3 (2.1–28.0) mg/ml in EGC. Higher levels of tyrosine, phenylalanine and tryptophan in the gastric juice were observed in individualsofEGCgroupscomparedthoseoftheNGDgroup(NGDvs.EGC,P,0.0001).ForthedetectionofEGC,theareas underthereceiveroperatingcharacteristiccurves(AUCs)ofeachbiomarkerwereasfollows:tyrosine,0.790[95%confidence interval (CI), 0.703–0.877]; phenylalanine, 0.831 (95% CI, 0.750–0.911); and tryptophan, 0.819 (95% CI, 0.739–0.900). The sensitivity and specificity of phenylalanine were 75.5% and 81.4%, respectively, for detection of EGC. A multiple logistic regressionanalysisshowedthathighlevelsofaromaticaminoacidsinthegastricjuicewereassociatedwithgastriccancer (adjustedbcoefficientsrangedfrom1.801to4.414,P,0.001). Conclusion:Increasedlevelsoftyrosine,phenylalanineandtryptophaninthegastricjuicesamplesweredetectedinthe early phase of gastric carcinogenesis. Thus, tyrosine, phenylalanine and tryptophan in gastric juice could be used as biomarkers for the early detection of gastric cancer. A gastric juice analysis i