High Human Herpesvirus 8 (HHV-8) Prevalence, Clinical Correlates and High Incidence among Recently HIV-1-Infected Subjects in Sao Paulo, Brazil 英文参考文献.docVIP

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High Human Herpesvirus 8 (HHV-8) Prevalence, Clinical Correlates and High Incidence among Recently HIV-1-Infected Subjects in Sao Paulo, Brazil 英文参考文献.doc

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High Human Herpesvirus 8 (HHV-8) Prevalence, Clinical Correlates and High Incidence among Recently HIV-1-Infected Subjects in Sao Paulo, Brazil 英文参考文献

HighHumanHerpesvirus8(HHV-8)Prevalence,Clinical CorrelatesandHighIncidenceamongRecentlyHIV-1- InfectedSubjectsinSaoPaulo,Brazil MarianaDiasBatista1,2,SuzeteFerreira3,MarianaM.Sauer1,HelenaTomiyama1,MariaTeresaMaidana Giret1,Cla′udioS.Pannuti4,RicardoS.Diaz1,EsterC.Sabino3,EsperG.Kallas1,5* 1Infectious Diseases Division, Federal University of Sa?o Paulo, Sa?o Paulo, Brazil, 2Department of Dermatology, Federal University of Sa?o Paulo, Sa?o Paulo, Brazil, 3Fundac?a?o Pro′-Sangue,Hemocentro,Sa?o Paulo,Brazil,4InstitutodeMedicinaTropical,UniversityofSa?o Paulo,Sa?o Paulo,Brazil,5DivisionofClinicalImmunologyand Allergy,UniversityofSa?o Paulo,Sa?o Paulo,Brazil Abstract Background: Human herpesvirus 8 (HHV-8) is the etiological agent for Kaposi Sarcoma, which occurs especially in HIV- infected subjects. HHV-8 infection and its clinical correlates have not been well characterized in recently HIV-1-infected subjects,especiallymenwhohavesexwithmen(MSM). Methodology/PrincipalFindings:WeassessedtheHHV-8seroprevalence,clinicalcorrelates,andincidenceafteroneyear of follow-up in a cohort of 228 recently HIV-1-infected individuals, of whom 83.6% were MSM, using indirect immunofluorescenceassay.TheprevalenceofHHV-8infectionatthetimeofcohortenrollmentwas25.9%(59/228).Inthe univariatemodel,thereweresignificantassociationswithmalegender,blackethnicity,MSMpractice,andprevioushepatitis Bvirusandsyphilisinfections.InthemultivariatemodelwecouldstilldemonstrateassociationwithMSM,hepatitisB,and blackethnicity.NodifferencesinmeanCD4+cellcountsorHIVviralloadaccordingtoHHV-8statuswerefound.Intermsof incidence,therewere23/127(18.1%)seroconversionsinthecohortafter1year. Conclusions:HHV-8ishighlyprevalentamongrecentlyHIV-1-infectedsubjects.Correlationswithothersexuallytransmitted infectionssuggestcommontransmissionroutes. Citation:BatistaMD,FerreiraS,SauerMM,TomiyamaH,GiretMTM,etal.(2009)HighHumanHerpesvirus8(HHV-8)Prevalence,ClinicalCorrelatesandHigh IncidenceamongRecentlyHIV-1-Infected