High N-Terminal Pro-B-Type Natriuretic Peptide Levels Are Associated with Reduced Heart Rate Variability in Acute Myocardial Infarction 英文参考文献.docVIP
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High N-Terminal Pro-B-Type Natriuretic Peptide Levels Are Associated with Reduced Heart Rate Variability in Acute Myocardial Infarction 英文参考文献
HighN-TerminalPro-B-TypeNatriureticPeptideLevels
AreAssociatedwithReducedHeartRateVariabilityin
AcuteMyocardialInfarction
LucLorgis1,DanielMoreau2,3,LaurentMock4,BernadetteDaumas1,2,DanielPotard1,4,ClaudeTouzery1,
YvesCottin1,3,MarianneZeller3*
1CentredeCardiologie,CHUDijon,Dijon,France,2Serviced’ExplorationFonctionnelle,CHUDijon,Dijon,France,3LaboratoiredePhysiopathologieetPharmacologie
Cardiome′taboliques,INSERMUMR866,UFRMe′decine,Universite′deBourgogne,Dijon,France,4ServicedeCardiologie,CliniquedeFontainelesDijon,FontainelesDijon,
France
Abstract
Aim:Weinvestigatedtherelationshipsbetweentheautonomicnervoussystem,asassessedbyheartratevariability(HRV)
andlevelsofN-terminalPro-B-typeNatriureticPeptide(Nt-proBNP)inpatientswithacutemyocardialinfarction(MI).
MethodsandResults:ThemeanofstandarddeviationofRRintervals(SDNN),thepercentageofRRintervalswith.50ms
variation (pNN50), square root of mean squared differences of successive RR intervals (rMSSD), and frequency domain
parameters (totalpower (TP),high frequency andlow frequency power ratio(LF/HF)) wereassessed by 24h HolterECG
monitoring.1018consecutivepatientsadmitted,24hforanacuteMIwereincluded.PlasmaNt-proBNP(Elecsys,Roche)
was measured from blood samples taken on admission. The median (IQR) Nt-proBNP level was 681(159–2432) pmol/L.
PatientswiththehighestquartileofNt-proBNPwereolder,withhigherrateofriskfactorsandlowerejectionfraction.The
highestNt-proBNPquartilegrouphadthelowestSDNN,LF/HFandtotalpowerbutsimilarpNN50andrMSSDlevels.Nt-
proBNP levels correlated negatively with SDNN (r=20.19, p,0.001), LF/HF (r=20.37, p,0.001), and LF (r=20.29,
p,0.001)butnotHF(r=20.043,p=0.172).Multipleregressionanalysisshowedthatplasmapropeptidelevelsremained
predictiveofLF/HF(B(SE)=20.065(0.015),p,0.001)),evenafteradjustmentforconfounders.
Conclusions:Inconclusion,ourpopulation-basedstudyhighlightstheimportanceofNt-proBNPlevelstopredictdecreased
HRVafteracuteMI.
Citation:LorgisL,MoreauD,MockL,DaumasB,PotardD,etal.(2012)HighN-Termi
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