Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells 英文参考文献.docVIP

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Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells 英文参考文献.doc

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Mesenchymal Stem Cells Promote Mammosphere Formation and Decrease E-Cadherin in Normal and Malignant Breast Cells 英文参考文献

MesenchymalStemCellsPromoteMammosphere FormationandDecreaseE-CadherininNormaland MalignantBreastCells AnnH.Klopp1.,LaraLacerda1,2,3.,AnshulGupta1,BisratG.Debeb1,TravisSolley1,LiLi1,ErikaSpaeth4, WeiXu1,XiaomeiZhang5,MichaelT.Lewis5,JamesM.Reuben6,SavitriKrishnamurthy7,MauroFerrari3, Roge′rioGaspar2,ThomasA.Buchholz1,MassimoCristofanilli8,FrankMarini4,MichaelAndreeff4, WendyA.Woodward1* 1DepartmentofRadiationOncology,TheUniversityofTexasMDAndersonCancerCenter,Houston,Texas,UnitedStatesofAmerica,2iMed.UL,FaculdadedeFarma′cia, Universidade de Lisboa, Lisbon, Portugal, 3Department of NanoMedicine and Biomedical Engineering, The University of Texas Health Science Center at Houston, Houston,Texas,UnitedStatesofAmerica, 4DepartmentofStemCellTransplantandCellularTherapy,TheUniversityofTexasMDAndersonCancerCenter,Houston, Texas, United States of America, 5Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas, United States of America, 6Department of Hematopathology,TheUniversityofTexasMDAndersonCancerCenter,Houston,Texas,UnitedStatesofAmerica,7DepartmentofPathology,TheUniversityofTexasMD AndersonCancerCenter, Houston,Texas,United StatesofAmerica, 8Breast MedicalOncology,TheUniversityofTexasMDAndersonCancerCenter,Houston, Texas, UnitedStatesofAmerica Abstract Introduction:Normalandmalignantbreasttissuecontainsararepopulationofmulti-potentcellswiththecapacitytoself- renew,referredtoasstemcells,ortumorinitiatingcells(TIC).Thesecellscanbeenrichedbygrowthas‘‘mammospheres’’in three-dimensionalcultures. Objective:Wetestedthehypothesisthathumanbone-marrowderivedmesenchymalstemcells(MSC),whichareknownto supporttumorgrowthandmetastasis,increasemammosphereformation. Results:WefoundthatMSCincreasedhumanmammaryepithelialcell(HMEC)mammosphereformationinadose-dependent manner.A similar increase in sphereformationwasseenin human inflammatory (SUM149) and non-inflammatory breast cancer cell lines (MCF-7) but not in primary inflammatory breast cancer cell