Metabolic Consequences and Vulnerability to Diet-Induced Obesity in Male Mice under Chronic Social Stress 英文参考文献.docVIP

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Metabolic Consequences and Vulnerability to Diet-Induced Obesity in Male Mice under Chronic Social Stress 英文参考文献.doc

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Metabolic Consequences and Vulnerability to Diet-Induced Obesity in Male Mice under Chronic Social Stress 英文参考文献

MetabolicConsequencesandVulnerabilitytoDiet- InducedObesityinMaleMiceunderChronicSocialStress AlessandroBartolomucci1*,AdervilleCabassi2,PaoloGovoni3,GrazianoCeresini4,CherylCero1 ,Daniela Berra1,HaroldDadomo1,PaoloFranceschini1,GiacomoDell’Omo5,StefanoParmigiani1. ,Paola Palanza1. 1DepartmentofEvolutionaryandFunctionalBiology,UniversityofParma,Parma,Italy,2DepartmentofInternalMedicine,NephrologyandHealthSciences,Universityof Parma,Parma,Italy,3DepartmentofExperimentalMedicine,UniversityofParma,Parma,Italy,4DepartmentofInternalMedicineandBiomedicalSciences,Universityof Parma,Parma,Italy,5OrnisItalica,Rome,Italy Abstract Social and psychological factors interact with genetic predisposition and dietary habit in determining obesity. However, relativelyfewpre-clinicalstudiesaddresstheroleofpsychosocialfactorsinmetabolicdisorders.Previousstudiesfromour laboratory demonstrated in male mice: 1) opposite status-dependent effect on body weight gain under chronic psychosocial stress; 2) a reduction in body weight in individually housed (Ind) male mice. In the present study these observations were extended to provide a comprehensive characterization of the metabolic consequences of chronic psychosocial stress and individual housing in adult CD-1 male mice. Results confirmed that in mice fed standard diet, dominant(Dom)andIndhadanegativeenergybalancewhilesubordinate(Sub)hadapositiveenergybalance.Locomotor activitywasdepressedinSubandenhancedinDom.HyperphagiaemergedforDomandSubandhypophagiaforInd.Dom alsoshowedaconsistentdecreaseofvisceralfatpadsweightaswellasincreasednorepinephrineconcentrationandsmaller adipocytes diameter in the perigonadal fat pad. On the contrary, under high fat diet Sub and, surprisingly, Ind showed higherwhileDomshowedlowervulnerabilitytoobesityassociatedwithhyperphagia.Inconclusion,wedemonstratedthat social status under chronic stress and individual housing deeply affect mice metabolic functions in different, sometime opposite, directions. Food intake,