Metadherin Mediates Lipopolysaccharide-Induced Migration and Invasion of Breast Cancer Cells 英文参考文献.docVIP

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Metadherin Mediates Lipopolysaccharide-Induced Migration and Invasion of Breast Cancer Cells 英文参考文献.doc

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Metadherin Mediates Lipopolysaccharide-Induced Migration and Invasion of Breast Cancer Cells 英文参考文献

MetadherinMediatesLipopolysaccharide-Induced MigrationandInvasionofBreastCancerCells YuhanZhao1.,XiaoliKong1.,XiaoyanLi1,ShiYan2,CunzhongYuan2,WenweiHu3*,QifengYang1* 1DepartmentofBreastSurgery,ShandongUniversitySchoolofMedicine,Jinan,Shandong,China,2DepartmentofObstetricsandGynecology,QiluHospital,Shandong UniversitySchoolofMedicine,Jinan,Shandong,China,3CancerInstituteofNewJersey,UniversityofMedicineandDentistryofNewJersey,NewBrunswick,NewJersey, UnitedStatesofAmerica Abstract Background:Breastcanceristhemostprevalentcancerinwomenworldwideandmetastaticbreastcancerhasverypoor prognosis.Inflammationhasbeenimplicatedinmigrationandmetastasisofbreastcancer,althoughtheexactmolecular mechanismremainselusive. PrincipalFindings:Weshowthatthepro-inflammatoryendotoxinLipopolysaccharide(LPS)upregulatestheexpressionof Metadherin (MTDH), a recently identified oncogene, in a number of breast cancer lines. Stable knockdown of MTDH by shRNAinhumanbreastMDA-MB-231cellsabolishesLPS-inducedcellmigrationandinvasionasdeterminedbyseveralin vitroassays.Inaddition,knockdownofMTDHdiminishesNuclearFactor-kappaB(NF-kB)activationbyLPSandinhibited LPS-inducedIL-8andMMP-9production. Conclusions:TheseresultsstronglysuggestthatMTDHisapivotalmoleculeininflammation-mediatedtumormetastasis. SinceNF-kB,IL-8andMMP-9playrolesinLPS-inducedinvasionormetastasis,themechanismofMTDH-promotedinvasion andmetastasismaybethroughtheactivationofNF-kB,IL-8andMMP-9,alsosuggestingaroleofMTDHinregulatingboth inflammatory responses and inflammation-associated tumor invasion. These findings indicate that MTDH is involved in inflammation-induced tumor progression, and support that MTDH targeting therapy may hold promising prospects in treatingbreastcancer. Citation:ZhaoY,KongX,LiX,YanS,YuanC,etal.(2011)MetadherinMediatesLipopolysaccharide-InducedMigrationandInvasionofBreastCancerCells.PLoS ONE6(12):e29363.doi:10.1371/journal.pone.0029363 Editor:JunLi,SunYat-senUniversityMedicalSchool,China ReceivedAugust10,2011;Accepte