Mutation K42R in Ribosomal Protein S12 Does Not Affect Susceptibility of Mycobacterium smegmatis 16S rRNA A-Site Mutants to 2-Deoxystreptamines 英文参考文献.docVIP

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Mutation K42R in Ribosomal Protein S12 Does Not Affect Susceptibility of Mycobacterium smegmatis 16S rRNA A-Site Mutants to 2-Deoxystreptamines 英文参考文献.doc

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Mutation K42R in Ribosomal Protein S12 Does Not Affect Susceptibility of Mycobacterium smegmatis 16S rRNA A-Site Mutants to 2-Deoxystreptamines 英文参考文献

MutationK42RinRibosomalProteinS12DoesNotAffect SusceptibilityofMycobacteriumsmegmatis16SrRNA A-SiteMutantsto2-Deoxystreptamines SarathK.Kalapala1,SvenN.Hobbie1,2,ErikC.Bo¨ttger1,DmitryShcherbakov1* 1Institutfu¨rMedizinischeMikrobiologie,Universita¨tZu¨rich,Zu¨rich,Switzerland,2Singapore-MITAllianceforResearchandTechnology(SMART),CentreforLifeSciences, Singapore,Singapore Abstract Recent studies have suggested that ribosomal protein S12 modulates 16S rRNA function and susceptibility to 2- deoxystreptamineaminoglycosides.Tostudywhetherthenon-restrictiveK42RmutationinRpsLaffects2-deoxystreptamine susceptibility in Mycobacterium smegmatis, we studied the drug susceptibility pattern of various mutants with genetic alterationsinthe16SrRNAdecodingA-siteinthecontextofwild-typeandmutantproteinS12.RpsLK42Rsubstitutionwas foundnottoaffectthedrugresistancepatternassociatedwithmutationalalterationsin16SrRNAH44. Citation:KalapalaSK,HobbieSN,Bo¨ttgerEC,ShcherbakovD(2010)MutationK42RinRibosomalProteinS12DoesNotAffectSusceptibilityofMycobacterium smegmatis16SrRNAA-SiteMutantsto2-Deoxystreptamines.PLoSONE5(8):e11960.doi:10.1371/journal.pone.0011960 Editor:AnilKumarTyagi,UniversityofDelhi,India ReceivedApril30,2010;AcceptedJune5,2010;PublishedAugust5,2010 Copyright: ? 2010 Kalapala et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbygrantfromtheEuropeanCommunity(PAR,FP7-HEALTH-2009-241476).URLoffunder’swebsite:http://cordis.europa.eu/ home_en.html.Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:dscherbakov@imm.uzh.ch Introduction mycin), two (neomycin, paromomycin) or three (lividomycin) additionalsugarsattachedtoposition5ofringII,whereasin4,6-