NaCl Potentiates Human Fibrocyte Differentiation 英文参考文献.docVIP

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NaCl Potentiates Human Fibrocyte Differentiation 英文参考文献.doc

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NaCl Potentiates Human Fibrocyte Differentiation 英文参考文献

NaClPotentiatesHumanFibrocyteDifferentiation NehemiahCox,DarrellPilling,RichardH.Gomer* DepartmentofBiology,TexasAMUniversity,CollegeStation,Texas,UnitedStatesofAmerica Abstract ExcessiveNaClintakeisassociatedwithavarietyoffibrosingdiseasessuchasrenalandcardiacfibrosis.Thisassociationhas beenattributedtoincreasedbloodpressureastheresultofhighNaClintake.However,studiesinpatientswithhighNaCl intakeandfibrosisrevealaconnectionbetweenNaClintakeandfibrosisthatisindependentofbloodpressure.Wefindthat increasing the extracellular concentration of NaCl to levels that may occur in human blood after high-salt intake can potentiate,inserum-freecultureconditions,thedifferentiationoffreshly-isolatedhumanmonocytesintofibroblast-likecells called fibrocytes. NaCl affects the monocytes directly during their adhesion. Potassium chloride and sodium nitrate also potentiatefibrocytedifferentiation.TheplasmaproteinSerumAmyloidP(SAP)inhibitsfibrocytedifferentiation.Highlevels ofextracellularNaClchangetheSAPHillcoefficientfrom1.7to0.8,andcauseafour-foldincreaseintheconcentrationof SAP needed to inhibit fibrocyte differentiation by 95%. Together, our data suggest that NaCl potentiates fibrocyte differentiation.NaCl-increasedfibrocytedifferentiationmaythuscontributetoNaCl-increasedrenalandcardiacfibrosis. Citation:CoxN,PillingD,GomerRH(2012)NaClPotentiatesHumanFibrocyteDifferentiation.PLoSONE7(9):e45674.doi:10.1371/journal.pone.0045674 Editor:GernotZissel,UniversityMedicalCenterFreiburg,Germany ReceivedMay1,2012;AcceptedAugust24,2012;PublishedSeptember18,2012 Copyright:?2012Coxetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This research was funded by Texas AM University. The funder had no role in study design, data collection and analysis, decision to publish, or preparationofthemanuscript. CompetingInterests:Theauthorsha