Mycobacterium tuberculosis Complex Enhances Susceptibility of CD4 T Cells to HIV through a TLR2-Mediated Pathway 英文参考文献.docVIP

下载本文档

5
0
约 7页
2017-05-12 发布于上海
举报
版权申诉

Mycobacterium tuberculosis Complex Enhances Susceptibility of CD4 T Cells to HIV through a TLR2-Mediated Pathway 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Mycobacterium tuberculosis Complex Enhances Susceptibility of CD4 T Cells to HIV through a TLR2-Mediated Pathway 英文参考文献

MycobacteriumtuberculosisComplexEnhances SusceptibilityofCD4TCellstoHIVthroughaTLR2- MediatedPathway SeemaM.Thayil1,Ya-ChiHo1,RobertC.Bollinger1,JoelN.Blankson1,RobertF.Siliciano1,2, PetrosC.Karakousis1,3*,KathleenR.Page1 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2Howard Hughes Medical Institute, Johns HopkinsUniversitySchoolofMedicine,Baltimore,Maryland,UnitedStatesofAmerica,3DepartmentofInternationalHealth,JohnsHopkinsBloombergSchoolofPublic Health,Baltimore,Maryland,UnitedStatesofAmerica Abstract AmongHIV-infectedindividuals,co-infectionwithMycobacteriumtuberculosisisassociatedwithfasterprogressiontoAIDS. WeinvestigatedthehypothesisthatM.bovisBCGandM.tuberculosis(Mtbcomplex)couldenhancesusceptibilityofCD4+ cells to HIV infection. Peripheral blood mononuclear cells (PBMCs) collected from healthy donors were stimulated with 2 + M.bovisBCG,M.tuberculosisCDC1551andM.smegmatisMC 155,andstimulatedCD4 cellswereinfectedwithR5-andX4- tropicsinglereplication-competentpseudovirus.CD4+cellsstimulatedwithMtbcomplexshowedenhancedinfectionwith R5-andX4-tropicHIV,comparedtounstimulatedcellsorcellsstimulatedwithM.smegmatis(p,0.01).TreatmentwithTLR2 siRNA reversed the increased susceptibility of CD4+ cells with R5- and X4-tropic virus induced by Mtb complex. These findingssuggestthatTBinfectionand/orBCGvaccinationmaybeariskfactorforHIVacquisition. Citation:ThayilSM,HoY-C,BollingerRC,BlanksonJN,SilicianoRF,etal.(2012)MycobacteriumtuberculosisComplexEnhancesSusceptibilityofCD4TCellstoHIV throughaTLR2-MediatedPathway.PLoSONE7(7):e41093.doi:10.1371/journal.pone.0041093 Editor:MiguelSantin,BarcelonaUniversityHospital,Spain ReceivedMarch21,2012;AcceptedJune18,2012;PublishedJuly23,2012 Copyright: ? 2012 Thayil et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalau