NEXCADE Perturbation Analysis for Complex Networks 英文参考文献.docVIP

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NEXCADE Perturbation Analysis for Complex Networks 英文参考文献.doc

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NEXCADE Perturbation Analysis for Complex Networks 英文参考文献

NEXCADE:PerturbationAnalysisforComplexNetworks GitanjaliYadav1*,SureshBabu2 1ComputationalBiologyLaboratory,NationalInstituteofPlantGenomeResearch,NewDelhi,India,2SchoolofHumanEcology,AmbedkarUniversity,NewDelhi,India Abstract Recentadvancesinnetworktheoryhaveledtoconsiderableprogressinourunderstandingofcomplexrealworldsystems and their behavior in response to external threats or fluctuations. Much of this research has been invigorated by demonstration of the ‘robust, yet fragile’ nature of cellular and large-scale systems transcending biology, sociology, and ecology,throughapplicationofthenetworktheorytodiverseinteractionsobservedinnaturesuchasplant-pollinator,seed- dispersalagentandhost-parasiterelationships.Inthiswork,wereportthedevelopmentofNEXCADE,anautomatedand interactive program for inducing disturbances into complex systems defined by networks, focusing on the changes in globalnetworktopologyandconnectivityasafunctionoftheperturbation.NEXCADEusesagraphtheoreticalapproachto simulateperturbationsinauser-definedmanner,singly,inclusters,orsequentially.Todemonstratethepromiseitholdsfor broader adoption by the research community, we provide pre-simulated examples from diverse real-world networks includingeukaryoticprotein-proteininteractionnetworks,fungalbiochemicalnetworks,avarietyofecologicalfoodwebsin natureaswellassocialnetworks.NEXCADEnotonlyenablesnetworkvisualizationateverystepofthetargetedattacks,but alsoallowsriskassessment,i.e.identificationofnodescriticalfortherobustnessofthesystemofinterest,inordertodevise andimplementcontext-basedstrategiesforrestructuringanetwork,ortoachieveresilienceagainstlinkornodefailures. Sourcecodeandlicenseforthesoftware,designedtoworkonaLinux-basedoperatingsystem(OS)canbedownloadedat http://www.nipgr.res.in/nexcade_download.html.Inaddition,wehavedevelopedNEXCADEasanOS-independentonline webserverfreelyavailabletothescientificcommunitywithoutanyloginrequirementathttp://www.nipgr.res.in/nexcade. html. Citation:YadavG,BabuS(20