O Antigen Allows B. parapertussis to Evade B. pertussis Vaccine–Induced Immunity by Blocking Binding and Functions of Cross-Reactive Antibodies 英文参考文献.docVIP
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O Antigen Allows B. parapertussis to Evade B. pertussis Vaccine–Induced Immunity by Blocking Binding and Functions of Cross-Reactive Antibodies 英文参考文献
OAntigenAllowsB.parapertussistoEvadeB.pertussis
Vaccine–InducedImmunitybyBlockingBindingand
FunctionsofCross-ReactiveAntibodies
XuqingZhang1,MariaEugeniaRodr?′guez2,EricT.Harvill1*
1DepartmentofVeterinaryandBiomedicalSciences,PennsylvaniaStateUniversity,UniversityPark,Pennsylvania,UnitedStatesofAmerica,2DepartmentofChemistry,
CentreofAppliedBiotechnology(CINDEFI,CCyTLaPlata),SchoolofScience,LaPlataUniversity,LaPlata,Argentina
Abstract
AlthoughtheprevalenceofBordetellaparapertussisvariesdramaticallyamongstudiesindifferentpopulationswithdifferent
vaccination regimens, there is broad agreement that whooping cough vaccines, composed only of B. pertussis antigens,
provide little if any protection against B. parapertussis. In C57BL/6 mice, a B. pertussis whole-cell vaccine (wP) provided
modestprotectionagainstB.parapertussis,whichwasdependentonIFN-c.ThewPwasmuchmoreprotectiveagainstan
isogenicB.parapertussisstrainlackingO-antigenthanitswild-typecounterpart.O-antigeninhibitedbindingofwP–induced
antibodiestoB.parapertussis,aswellasantibody-mediatedopsonophagocytosisinvitroandclearanceinvivo .aP–induced
antibodies also bound better in vitro totheO-antigen mutantthan towild-type B. parapertussis,but aP failed toconfer
protection against wild-type or O antigen–deficient B. parapertussis in mice. Interestingly, B. parapertussis–specific
antibodiesprovidedinadditiontoeitherwPoraPweresufficienttoveryrapidlyreduceB.parapertussisnumbersinmouse
lungs.Thisstudyidentifiesamechanismbywhichonepathogenescapesimmunityinducedbyvaccinationagainstaclosely
relatedpathogenandmayexplainwhyB.parapertussisprevalencevariessubstantiallybetweenpopulationswithdifferent
vaccinationstrategies.
Citation:ZhangX,Rodr?′guezME,HarvillET(2009)OAntigenAllowsB.parapertussistoEvadeB.pertussisVaccine–InducedImmunitybyBlockingBindingand
FunctionsofCross-ReactiveAntibodies.PLoSONE4(9):e6989.doi:10.1371/journal.pone.0006989
Editor:UlrichA.Maus,HannoverSchoolofMedicine,Germany
ReceivedJune11,2009;AcceptedAugust19
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