Null Mutations in EphB Receptors Decrease Sharpness of Frequency Tuning in Primary Auditory Cortex 英文参考文献.docVIP
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Null Mutations in EphB Receptors Decrease Sharpness of Frequency Tuning in Primary Auditory Cortex 英文参考文献
NullMutationsinEphBReceptorsDecreaseSharpnessof
FrequencyTuninginPrimaryAuditoryCortex
IrakliIntskirveli,RajuMetherate,KarinaS.Cramer*
DepartmentofNeurobiologyandBehaviorandCenterforHearingResearch,UniversityofCaliforniaIrvine,Irvine,California,UnitedStatesofAmerica
Abstract
Primary auditory cortex (A1) exhibits a tonotopic representation of characteristic frequency (CF). The receptive field
properties of A1 neurons emerge from a combination of thalamic inputs and intracortical connections. However, the
mechanisms that guide growth of these inputs during development and shape receptive field properties remain largely
unknown. We previously showed that Eph family proteins help establish tonotopy in the auditory brainstem. Moreover,
otherstudieshaveshownthattheseproteinsshapetopographyinvisualandsomatosensorycortices.Here,weexamined
thecontributionofEphproteinstocorticalorganizationofCF,responsethresholdsandsharpnessoffrequencytuning.We
examined mice with null mutations in EphB2 and EphB3, as these mice show significant changes in auditory brainstem
connectivity.WemappedA1usinglocalfieldpotentialrecordingsinadultEphB22/2;EphB32/2andEphB32/2mice,andina
centralA1locationinserteda16-channelprobetomeasuretone-evokedcurrent-sourcedensity(CSD)profiles.Basedonthe
shortest-latencycurrentsinkinthemiddlelayers,whichreflectsputativethalamocorticalinput,wedeterminedfrequency
receptive fields and sharpness of tuning (Q20) for each recording site. While both mutant mouse lines demonstrated
increasingCFvaluesfromposteriortoanteriorA1similartowildtypemice,wefoundthatthedoublemutantmicehad
significantlylowerQ20valuesthaneitherEphB32/2miceorwildtypemice,indicatingbroadertuning.Inaddition,wefound
thatthedoublemutantshadsignificantlyhigherCFthresholdsandlongeronsetlatencyatthresholdthanmicewithwild
typeEphB2.TheseresultsdemonstratethatEphBreceptors influenceauditorycorticalresponses,andsuggestthatEphB
signalinghasmultiplefunctionsinauditorysystemdevelopment.
Citation:IntskirveliI,M
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