Number and mode of inheritance of QTL influencing backfat thickness on SSC2p in Sino-European pig pedigrees 英文参考文献.docVIP
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Number and mode of inheritance of QTL influencing backfat thickness on SSC2p in Sino-European pig pedigrees 英文参考文献
Tortereauetal.GeneticsSelectionEvolution2011,43:11
/content/43/1/11
G
enetics
Selection
Evolution
RESEARCH
OpenAccess
NumberandmodeofinheritanceofQTL
influencingbackfatthicknessonSSC2p
inSino-Europeanpigpedigrees
FlavieTortereau1,3*,HélèneGilbert2,HenriCMHeuven3,Jean-PierreBidanel2,MartienAMGroenen3and
JulietteRiquet1
Abstract
Background:Inthepig,multipleQTLassociatedwithgrowthandfatnesstraitshavebeenmappedto
chromosome2(SSC2)andamongthese,atleastoneshowspaternalexpressionduetotheIGF2-intron3-G3072A
substitution.PreviouslypublishedresultsonthepositionandimprintingstatusofthisQTLdisagreebetween
analysesfromFrenchandDutchF2crossbredpigpopulationsobtainedwiththesamebreeds(Meishancrossed
withLargeWhiteorLandrace).
Methods:TostudytheroleofpaternalandmaternalallelesattheIGF2locusandtotestthehypothesisofa
secondQTLaffectingbackfatthicknessontheshortarmofSSC2(SSC2p),aQTLmappinganalysiswascarriedout
onacombinedpedigreeincludingboththeFrenchandDutchF2populations,ontheprogenyofF1malesthat
wereheterozygous(A/G)andhomozygous(G/G)attheIGF2locus.Simulationswereperformedtoclarifythe
relationsbetweenthetwoQTLandtounderstandtowhatextenttheycanexplainthediscrepanciespreviously
reported.
Results:TheQTLanalysesshowedthesegregationofatleasttwoQTLonchromosome2inbothpedigrees,i.e.
theIGF2locusandasecondQTLsegregatingatleastintheG/GF1malesandlocatedbetweenpositions30and
51cM.StatisticalanalyseshighlightedthatthematernallyinheritedalleleattheIGF2locushadasignificanteffect
butsimulationstudiesshowedthatthisisprobablyaspuriouseffectduetothesegregationofthesecondQTL.
Conclusions:OurresultsshowthattwoQTLonSSC2paffectbackfatthickness.Differencesinthepedigree
structuresandinthenumberofheterozygousfemalesattheIGF2locusresultindifferentimprintingstatusesin
thetwopedigreesstudied.ThespuriouseffectobservedwhenamaternallyalleleispresentattheIGF2locus,isin
factduetothepresenceofasecondcloselylocatedQTL.Thisworkconfirmsthatpigchromosome2isamajor
regionassociatedwithfatteningtraits.
Introduction
gene in
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