Odontostomatologic management of patients receiving oral anticoagulant therapy a retrospective multicentric study 英文参考文献.docVIP

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Odontostomatologic management of patients receiving oral anticoagulant therapy a retrospective multicentric study 英文参考文献.doc

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Odontostomatologic management of patients receiving oral anticoagulant therapy a retrospective multicentric study 英文参考文献

Inchingoloetal.AnnalsofSurgicalInnovationandResearch2011,5:5 /content/5/1/5 RESEARCH ARTICLE OpenAccess Odontostomatologicmanagementofpatients receivingoralanticoagulanttherapy: Aretrospectivemulticentricstudy FrancescoInchingolo1,4*,MarcoTatullo2,4,FabioMAbenavoli3,MassimoMarrelli4,AlessioDInchingolo5, SalvatoreScacco2,FrancescoPapa1,AngeloMInchingolo6andGiannaDipalma4 Abstract Introduction:Today,wefrequentlyfindpatientstakingoralanticoagulanttherapy(OAT),aprophylaxisagainstthe occurrenceofthromboembolicevents.Anoralsurgeonneedstoknowhowtobettermanagesuchpatients,in ordertoavoidhemorrhagicandthromboemboliccomplications. Materialsandmethods:Agroupof193patients(119menagedbetween46and82and74womenaged between54and76)undergoingOATformorethan5yearsweremanagedwithastandardizedmanagement protocolanda2-monthsfollow-up.Theaimofthepresentstudywastoapplyaprotocol,whichcouldprovidea safeintra-andpostoperativemanagementofpatientsonOAT. Results:Amongthe193patients,only2hadpostoperativecomplications. Conclusions:Wethinkthattheprotocolusedinthepresentstudycanbeusedforcompletesafetyinthe treatmentofthistypeofpatients. Keywords:OralAnticoagulantTherapy(OAT),TranexamicAcid,OralSurgery Introduction ? acenocoumarol: intermediate action, which begins Thetypologyofcoagulationdisordersisextremelyhet- within24-48handendswithin2-4days. erogeneous. Today, we frequently treat patients taking oralanticoagulanttherapy(OAT),aprophylaxisagainst theoccurrenceofthromboembolicevents[1,2]. ?warfarin:longanddelayedactionfrom3to7days. Warfarin has a more permanent and long-lasting effect, because of its longer biological half-life (about Recent studies on the Italian population indicate an 36h). estimated250.000patientstakingOATtodate.Indica- Theaimofthepresentstudywastoapplyaprotocol, tions for use of this pharmacological prophylaxis [3,4] which could provide a safe intra- and postoperative are confirmed by cardiac diseases, vasculopathies with managementofpatientsonOAT. thromboembolic etiolo