Omentum-Wrapped Scaffold with Longitudinally Oriented Micro-Channels Promotes Axonal Regeneration and Motor Functional Recovery in Rats 英文参考文献.docVIP

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Omentum-Wrapped Scaffold with Longitudinally Oriented Micro-Channels Promotes Axonal Regeneration and Motor Functional Recovery in Rats 英文参考文献.doc

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Omentum-Wrapped Scaffold with Longitudinally Oriented Micro-Channels Promotes Axonal Regeneration and Motor Functional Recovery in Rats 英文参考文献

Omentum-WrappedScaffoldwithLongitudinally OrientedMicro-ChannelsPromotesAxonalRegeneration andMotorFunctionalRecoveryinRats Yong-GuangZhang1,2.,Jing-HuiHuang1.,Xue-YuHu1.,Qing-SongSheng3,WeiZhao4,Zhuo-JingLuo1* 1Institution of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi’an, China, 2476 Clinical Division, Fuzhou General Hospital, Fuzhou, China, 3DepartmentofObstetricsandGynecology,XijingHospital,FourthMilitaryMedicalUniversity,Xi’an,China,4DepartmentofBiochemistryandMolecularBiology,Basic MedicalScienceCollege,NingxiaMedicalUniversity,Yinchuan,China Abstract Background:Tissue-engineerednervescaffoldsholdgreatpotentialinbridginglargeperipheralnervedefects.However, insufficient vascularization of nerve scaffolds limited neural tissues survival and regeneration, which hampered the successfulimplantationandclinicalapplicationofnervescaffolds.Theomentumpossessesahighvascularizationcapacity andenhancesregenerationandmaturationoftissuesandconstructstowhichitisapplied.However,combinedapplication ofnervescaffoldsandomentumonaxonalregenerationandfunctionalrecoveryinthetreatmentoflargeperipheralnerve defectshasrarelybeeninvestigatedthusfar. Methods:Inthepresentstudy,anomentum-wrappedcollagen-chitosanscaffoldwasusedtobridgea15-mm-longsciatic nerve defect in rats. Rats that received nerve autografts or scaffolds alone were served as positive control or negative control,respectively.Theaxonalregenerationandfunctionalrecoverywereexaminedbyacombinationofwalkingtrack analysis, electrophysiological assessment, Fluoro-Gold (FG) retrograde tracing, as well as morphometric analyses to both regeneratednervesandtargetmuscles. Findings:Theresultsdemonstratedthataxonalregenerationandfunctionalrecoverywereinthesimilarrangebetweenthe omentum-wrappinggroupandtheautograftgroup,whichweresignificantlybetterthanthoseinthescaffoldalonegroup. Further investigation showed that the protein levels of vascular endothelial growth factor (VEGF), brain-derived neurotrophicfactor