Oncogenic Potential of Hepatitis C Virus Proteins 英文参考文献.docVIP

Viruses 2010, 2, 2108-2133; doi:10.3390/v2092108 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review Oncogenic Potential of Hepatitis C Virus Proteins Arup Banerjee 1, Ratna B. Ray 2 and Ranjit Ray 1,3,* 1 Department of Internal Medicine, Edward A. Doisy Research Center, 1100 S. Grand Blvd., 8th Floor, St. Louis, MO 63104, USA; E-Mail: abanerj1@ 2 Department of Pathology, Edward A. Doisy Research Center, 1100 S. Grand Blvd., 2nd Floor, St. Louis, MO 63104, USA; E-Mail: rayrb@ 3 Molecular Microbiology Immunology, Edward A. Doisy Research Center, 1100 S. Grand Blvd., 8th Floor, St. Louis, MO 63104, USA * Author to whom correspondence should be addressed; E-Mail: rayr@; Tel.: 1-314- 977-9034; Fax: 1-314-771-3816. Received: 15 July 2010; in revised form: 23 September 2010 / Accepted: 24 September 2010 / Published: 27 September 2010 Abstract: Chronic hepatitis C virus (HCV) infection is a major risk factor for liver disease progression, and may lead to cirrhosis and hepatocellular carcinoma (HCC). The HCV genome contains a single-stranded positive sense RNA with a cytoplasmic lifecycle. HCV proteins interact with many host-cell factors and are involved in a wide range of activities, including cell cycle regulation, transcriptional regulation, cell proliferation, apoptosis, lipid metabolism, and cell growth promotion. Increasing experimental evidences suggest that HCV contributes to HCC by modulating pathways that may promote malignant transformation of hepatocytes. At least four of the 10 HCV gene products, namely core, NS3, NS5A and NS5B play roles in several potentially oncogenic pathways. Induction of both endoplasmic reticulum (ER) stress and oxidative stress by HCV proteins may also contribute to hepatocyte growth promotion. The current review identifies important functions of the viral proteins connecting HCV infections and potential for development of HCC. Ho