Origination of the Split Structure of Spliceosomal Genes from Random Genetic Sequences 英文参考文献.docVIP

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Origination of the Split Structure of Spliceosomal Genes from Random Genetic Sequences 英文参考文献.doc

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Origination of the Split Structure of Spliceosomal Genes from Random Genetic Sequences 英文参考文献

OriginationoftheSplitStructureofSpliceosomalGenes fromRandomGeneticSequences RahulRegulapati1.,AshwiniBhasi2.,ChandanKumarSingh3,PeriannanSenapathy2,3* 1DepartmentofBiotechnology,IndianInstituteofTechnologyMadras,Chennai,India,2DepartmentofHumanGenetics,GenomeInternationalCorporation,Madison, Wisconsin,UnitedStatesofAmerica,3DepartmentofBioinformatics,InternationalCenterforAdvancedGenomicsandProteomics,NehruNagar,Chennai,India Abstract Themechanismbywhichprotein-codingportionsofeukaryoticgenescametobeseparatedbylongnon-codingstretches ofDNA,andthepurposeforthisperplexingarrangement,haveremainedunresolvedfundamentalbiologicalproblemsfor threedecades.Wereporthereaplausiblesolutiontothisproblembasedonanalysisofopenreadingframe(ORF)length constraints in the genomes of nine diverse species. If primordial nucleic acid sequences were random in sequence, functionalproteinsthatareinnatelylongwouldnotbeencodedduetothefrequentoccurrenceofstopcodons.Thebest possible way that a long protein-coding sequence could have been derived was by evolving a split-structure from the randomDNA(orRNA)sequence.Resultsofthesystematicanalysesofninecompletegenomesequencespresentedhere suggests that perhaps the major underlying structural features of split-genes have evolved due to the indigenous occurrenceofsplitprotein-codinggenesinprimordialrandomnucleotidesequence.Theresultsalsosuggestthatintron- richgenescontainingshortexonsmayhavebeentheoriginalformofgenesintrinsicallyoccurringinrandomDNA,andthat intron-poorgenescontaininglongexonswereperhapsderivedfromtheoriginalintron-richgenes. Citation:RegulapatiR,BhasiA,SinghCK,SenapathyP(2008)OriginationoftheSplitStructureofSpliceosomalGenesfromRandomGeneticSequences.PLoS ONE3(10):e3456.doi:10.1371/journal.pone.0003456 Editor:DawnField,NERCCentreforEcologyandHydrology,UnitedKingdom ReceivedFebruary21,2008;AcceptedAugust1,2008;PublishedOctober20,2008 Copyright: ?2008 Senapathy et al. This isan open-access article distributed under the terms of the Cr