Osteoarthritis and a high-fat diet the full OA syndrome in a small animal model 英文参考文献.docVIP

van der Kraan Arthritis Research Therapy 2010,12:130 /content/12/4/130 EDITORIAL Osteoarthritis and a high-fat diet: the full ‘OA syndrome’ in a small animal model Peter M van der Kraan* See related research by Gri? n et al., /content/12/4/R130 high-fat fed mice was observed. Mice on the high-fat diet Abstract could be divided into ‘low gainer’ (LG; low body mass Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Gri?n and co-workers in this issue of Arthritis and fat) and ‘high gainer’ (HG; high body mass and fat) populations depending on their extent of weight gain. An explanation for this enigmatic ? nding in an inbred mouse strain is not obvious, but di? erences in social status and Research and Therapy shows that a high-fat diet leads related elevated stress levels might play a r e to obesity and OA in the studied animals and that this is related to alterations in locomotor function. Furthermore, a high-fat diet leads to pain sensitization and depression/anxiety-like behavior unrelated to structural OA changes in the knee. Their ?ndings demonstrate that the majority of features of the human ‘OA syndrome’can be reproduced in a small animal model. HG mice showed an increased incidence of knee OA, mainly indicated by loss of cartilage proteoglycans. So high susceptibility to obesity was associated with OA-like changes in the knee joint. Since the HG phenotype seems to be the consequence of a combination of both a high- fat diet and high stress levels, one might speculate that high stress levels play a role in OA development in these animals. It can be anticipated that high stress levels will have an e? ect on corticosteroid levels and activity of the mice. Osteoarthritis (OA) is the most common joint disease Gri? n and colleagues further tested whether diet, fat and a? ects a large pr