Organic Synthesis in Pheromone Science 英文参考文献.docVIP

Molecules 2005, 10, 1023-1047 molecules ISSN 1420-3049 Keynote Lecture Organic Synthesis in Pheromone Science Kenji Mori Emeritus Professor, The University of Tokyo, 1-20-6-1309, Mukogaoka, Bunkyo-ku, Tokyo 113-0023, Japan, Fax: (+81)-3-3816-6889. E-mail: kjk-mori@arion.ocn.ne.jp Received: 23 April 2005 / Published: 30 September 2005 Abstract: Examples are given to illustrate the use of chemical and/or enzymatic asymmetric reactions in the synthesis of the new pheromones of the broad-horned flour beetle, flea beetle, currant stem girdler and Colorado potato beetle. The relationships between stereochemistry and bioactivity among pheromones are summarized to emphasize biodiversity as revealed in pheromone perception. Keywords: Enantioselective synthesis; Lactone; Lipase; Pheromones; Terpenes Thank you for your kind introduction. I also thank Profs. Tkachev and De Kimpe for their kind invitation to attend this conference. This is my first visit to Siberia and I really expect to see something new in Altai mountains after the Conference. May I have the first PowerPoint picture, please… Figure 1 Organic Synthesis in Pheromone Science 1. Synthesis as Structural Proof 2. Synthesis for Large-Scale Preparation 3. Synthesis to Clarify the Structure-Activity Relationship Kenji Mori Emeritus Professor, The University of Tokyo Consultant, Fuji Flavor Co., Insect Pheromone and Traps Division Consultant, RIKEN Research Center for Allergy and Immunology  Molecules 2005, 10 1024 Today I would like to tell you about these three aspects in organic synthesis related to pheromone science: No. 1; Synthesis can prove or disprove the proposed structure of a pheromone. No. 2: Synthesis can provide a substantial amount of a useful pheromone. No. 3: Synthesis can clarify the structure-activity relationships among pheromones (Figure 1). Figure 2 Synthesis and Pheromone Activity of Bombykol and Its Isomers OH 12