Order and Stochastic Dynamics in Drosophila Planar Cell Polarity 英文参考文献.docVIP

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Order and Stochastic Dynamics in Drosophila Planar Cell Polarity 英文参考文献.doc

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Order and Stochastic Dynamics in Drosophila Planar Cell Polarity 英文参考文献

OrderandStochasticDynamicsinDrosophilaPlanarCell Polarity YoramBurak1,2,BorisI.Shraiman2,3 * 1CenterforBrainScience,HarvardUniversity,Cambridge,Massachusetts,UnitedStatesofAmerica,2KavliInstituteforTheoreticalPhysics,UniversityofCalifornia,Santa Barbara,SantaBarbara,California,UnitedStatesofAmerica,3DepartmentofPhysics,UniversityofCalifornia,SantaBarbara,SantaBarbara,California,UnitedStatesofAmerica Abstract Cells in the wing blade of Drosophila melanogaster exhibit an in-plane polarization causing distal orientation of hairs. EstablishmentofthePlanarCellPolarity(PCP)involvesintercellularinteractionsaswellasaglobalorientingsignal.Manyof the genetic and molecular components underlying this process have been experimentally identified and a recently advanced system-level model has suggested that the observed mutant phenotypes can be understood in terms of intercellular interactions involving asymmetric localization of membrane bound proteins. Among key open questions in understanding the emergence of ordered polarization is the effect of stochasticity and the role of the global orienting signal.Theseissuesrelatecloselytoourunderstandingofferromagnetisminphysicalsystems.Herewepursuethisanalogy to understand the emergence of PCP order. To this end we develop a semi-phenomenological representation of the underlying molecular processes and define a ‘‘phase diagram’’ of the model which provides a global view of the dependenceofthephenotypeonparameters.WeshowthatthedynamicsofPCPhastworegimes:rapidgrowthinthe amplitudeoflocalpolarizationfollowedbyaslowerprocessofalignmentwhichprogressesfromsmalltolargescales.We discusstheresponseofthetissuetovarioustypesoforientingsignalsandshowthatglobalPCPordercanbeachievedwith aweakorientingsignalprovidedthatitactsduringtheearlyphaseoftheprocess.Finallywedefineanddiscusssomeofthe experimentalpredictionsofthemodel. Citation: Burak Y, Shraiman BI (2009) Order and Stochastic Dynamics in Drosophila Planar Cell Polarity. PLoS Comput Biol 5(12