Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKsNF-κB-Mediated Inflammatory Responses 英文参考文献.docVIP

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Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKsNF-κB-Mediated Inflammatory Responses 英文参考文献.doc

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Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKsNF-κB-Mediated Inflammatory Responses 英文参考文献

PaeoniflorinProtectsagainstIschemia-InducedBrain DamagesinRatsviaInhibitingMAPKs/NF-kB-Mediated InflammatoryResponses Ruo-BingGuo1.,Guo-FengWang2.,An-PengZhao1,JunGu1,Xiu-LanSun1*,GangHu1* 1Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, China, 2Department of Cadre Ward No.3, the GeneralHospitalofJinanMilitaryAreaCommandofPLA,Jinan,China Abstract Paeoniflorin(PF),theprincipalcomponentofPaeoniaeRadixprescribedintraditionalChinesemedicine,hasbeenreported toexhibitmanypharmacologicaleffectsincludingprotectionagainstischemicinjury.However,themechanismsunderlying theprotectiveeffectsofPFoncerebralischemiaarestillunderinvestigation.ThepresentstudyshowedthatPFtreatment for 14 days could significantly inhibit transient middle cerebral artery occlusion (MCAO)-induced over-activation of astrocytesandmicroglia,andpreventedup-regulationsofpro-inflamamtorymediators(TNFa,IL-1b,iNOS,COX2and5-LOX) inplasmaandbrain.FurtherstudydemonstratedthatchronictreatmentwithPFsuppressedtheactivationsofJNKandp38 MAPK, but enhanced ERK activation. And PF could reverse ischemia-induced activation of NF-kB signaling pathway. Moreover,ourinvitrostudyrevealedthatPFtreatmentprotectedagainstTNFa-inducedcellapoptosisandneuronalloss. Taken together, the present study demonstrates that PF produces a delayed protection in the ischemia-injured rats via inhibiting MAPKs/NF-kB mediated peripheral and cerebral inflammatory response. Our study reveals that PF might be a potentialneuroprotectiveagentforstroke. Citation:GuoR-B,WangG-F,ZhaoA-P,GuJ,SunX-L,etal.(2012)PaeoniflorinProtectsagainstIschemia-InducedBrainDamagesinRatsviaInhibitingMAPKs/NF- kB-MediatedInflammatoryResponses.PLoSONE7(11):e49701.doi:10.1371/journal.pone.0049701 Editor:CesarV.Borlongan,UniversityofSouthFlorida,UnitedStatesofAmerica ReceivedMay5,2012;AcceptedOctober12,2012;PublishedNovember14,2012 Copyright:?2012Guoetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreative