Paternal Genetic Structure of Hainan Aborigines Isolated at the Entrance to East Asia 英文参考文献.docVIP

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Paternal Genetic Structure of Hainan Aborigines Isolated at the Entrance to East Asia 英文参考文献.doc

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Paternal Genetic Structure of Hainan Aborigines Isolated at the Entrance to East Asia 英文参考文献

PaternalGeneticStructureofHainanAboriginesIsolated attheEntrancetoEastAsia DongnaLi1,HuiLi2,3*,CaiyingOu1,YanLu2,YuantianSun1,BoYang4,ZhendongQin2,ZhenjianZhou1, ShilinLi2,LiJin2 1DepartmentofBiology,HainanMedicalCollege,Haikou,Hainan,China,2MOEKeyLaboratoryofContemporaryAnthropology,SchoolofLifeSciences,FudanUniversity, Shanghai,China, 3Department ofGenetics,School ofMedicine, Yale University, New Haven,Connecticut, United States ofAmerica, 4Department ofAnatomy, Third MilitaryMedicalUniversity,Chongqing,China Abstract Background: Atthesouthern entrancetoEastAsia, earlypopulationmigration hasaffected mostoftheY-chromosome variationsofEastAsians. Methodology/Principal Findings: To assess the isolated genetic structure of Hainan Island and the original genetic structureatthesouthernentrance,westudiedtheYchromosomediversityof405HainanIslandaboriginesfromallthesix populations,whohavelittleinfluenceoftherecentmainlandpopulationrelocationsandadmixtures.Herewereportthat haplogroupsO1a*andO2a*aredominantamongHainanaborigines.Inaddition,thefrequencyofthemainlanddominant haplogroup O3 is quite low among these aborigines, indicating that they have lived rather isolated. Clustering analyses suggests that the Hainan aborigines have been segregated since about 20 thousand years ago, after two dominant haplogroupsenteredEastAsia(31to36thousandyearsago). Conclusions/Significance:OurresultssuggestthatHainanaborigineshavebeenisolatedattheentrancetoEastAsiafor about20thousandyears,whosedistinctivegeneticcharacteristicscouldbeusedasimportantcontrolsinmanypopulation geneticstudies. Citation:LiD,LiH,OuC,LuY,SunY,etal.(2008)PaternalGeneticStructureofHainanAboriginesIsolatedattheEntrancetoEastAsia.PLoSONE3(5):e2168. doi:10.1371/journal.pone.0002168 Editor:VincentMacaulay,UniversityofGlasgow,UnitedKingdom ReceivedJanuary31,2008;AcceptedApril1,2008;PublishedMay14,2008 Copyright:?2008Lietal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpe