Pharmacological Effects of Rutaecarpine as a Cardiovascular Protective Agent 英文参考文献.docVIP

Molecules 2010, 15, 1873-1881; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Pharmacological Effects of Rutaecarpine as a Cardiovascular Protective Agent Sujie Jia 1 and Changping Hu 2,* 1 Department of Pharmaceutics, The Third XiangYa Hospital of Central South University, Changsha 410013, China; E-Mail: sujiejia@ 2 Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China * Author to whom correspondence should be addressed; E-Mail: huchangping@; Tel.: +086-731 Fax: +086-731 Received: 3 February 2010; in revised form: 1 March 2010 / Accepted: 8 March 2010 / Published: 15 March 2010 Abstract: Many studies indicate that traditional Chinese herbs are beneficial in the prevention and treatment of cardiovascular diseases. Evodia rutaecarpa (‘Wu-Chu-Yu’) remains the most popular and multi-purpose herb traditionally used in China for treatment of headache, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea. Rutaecarpine is one of the intriguing indolopyridoquinazoline alkaloids isolated from ‘Wu-Chu-Yu’. Rutaecarpine has been shown to have cardiovascular biological effects such as inotropic and chronotropic, vasorelaxant, anti-platelet aggregation and anti-inflammatory effects. Furthermore, it has been reported that rutaecarpine has beneficial effects on some cardiovascular diseases. This review summarizes data on the cardiovascular pharmacological actions of rutaecarpine the published over the recent years, aiming to provide more evidence supporting its use in the treatment of cardiovascular diseases. Keywords: rutaecarpine; cardiac protection; vasodilator; anti platelet aggregation; anti inflammation  Molecules 2010, 15 1874 1. Introduction Rutaceous plants, especially Evodia rutaecarpa (whose dried fruit is named ‘Wu-Chu-Yu’ in China), have