Pressure-dependent stress relaxation in acute respiratory distress syndrome and healthy lungs an investigation based on a viscoelastic model 英文参考文献.docVIP

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Pressure-dependent stress relaxation in acute respiratory distress syndrome and healthy lungs an investigation based on a viscoelastic model 英文参考文献.doc

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Pressure-dependent stress relaxation in acute respiratory distress syndrome and healthy lungs an investigation based on a viscoelastic model 英文参考文献

Available online /content/13/6/R199 Research Open Access Vol 13 No 6 Pressure-dependent stress relaxation in acute respiratory distress syndrome and healthy lungs: an investigation based on a viscoelastic model Steven Ganzert1, Knut M?ller2, Daniel Steinmann1, Stefan Schumann1 and Josef Guttmann1 1Department of Anesthesiology and Critical Care Medicine, University Medical Center, Freiburg, Hugstetter Str. 55, D-79106 Freiburg, Germany 2Department of Biomedical Engineering, Furtwangen University, Villingen-Schwenningen Campus, Jakob Kienzle Str. 17, D-78054 Villingen- Schwenningen, Germany Corresponding author: Steven Ganzert, steven.ganzert@uniklinik-freiburg.de Received: 10 Jul 2009 Revisions requested: 14 Sep 2009 Revisions received: 17 Nov 2009 Accepted: 9 Dec 2009 Published: 9 Dec 2009 Critical Care 2009, 13:R199 (doi:10.1186/cc8203) This article is online at: /content/13/6/R199 ? 2009 Ganzert et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Limiting the energy transfer between ventilator and lung is crucial for ventilatory strategy in acute respiratory distress syndrome (ARDS). Part of the energy is transmitted to the viscoelastic tissue components where it is stored or dissipates. In mechanically ventilated patients, viscoelasticity can be investigated by analyzing pulmonary stress relaxation. While stress relaxation processes of the lung have been intensively investigated, non-linear interrelations have not been systematically analyzed, and such analyses have been limited to small volume or pressure ranges. In this study, stress relaxation of mechanically ventilated lungs was investigated, focusing on non-linear dependence on pressure. The range o