Protective Effects of Extracts and Flavonoids Isolated from Scutia buxifolia Reissek against Chromosome Damage in Human Lymphocytes Exposed to Hydrogen Peroxide 英文参考文献.docVIP

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Protective Effects of Extracts and Flavonoids Isolated from Scutia buxifolia Reissek against Chromosome Damage in Human Lymphocytes Exposed to Hydrogen Peroxide 英文参考文献.doc

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Protective Effects of Extracts and Flavonoids Isolated from Scutia buxifolia Reissek against Chromosome Damage in Human Lymphocytes Exposed to Hydrogen Peroxide 英文参考文献

Molecules 2012, 17, 5757-5769; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Protective Effects of Extracts and Flavonoids Isolated from Scutia buxifolia Reissek against Chromosome Damage in Human Lymphocytes Exposed to Hydrogen Peroxide Aline Augusti Boligon 1,*, Michele Rorato Sagrillo 2,3, Luiz Filipe Machado 3, Olmiro de Souza Filho 3, Michel Mansur Machado 4, Ivana Beatrice Manica da Cruz 3 and Margareth Linde Athayde 1 1 Program of Post-Graduation in Pharmaceutical Sciences, Federal University of Santa Maria, Campus Camobi, Santa Maria, RS, 97105-900, Brazil 2 Franciscan University Center – UNIFRA, Andradas Street, 1614, Santa Maria, RS 97010-032, Brazil 3 Program of Post-Graduation in Pharmacology, Federal University of Santa Maria, Campus Camobi, Santa Maria, RS, 97105-900, Brazil 4 Federal University of Pampa – UNIPAMPA, Uruguaiana, RS 97500-970, Brazil * Author to whom correspondence should be addressed; E-Mail: alineboligon@; Tel.: +55-55-3220-9618. Received: 26 March 2012; in revised form: 25 April 2012 / Accepted: 26 April 2012 / Published: 14 May 2012 Abstract: Flavonoids are claimed to protect against cardiovascular disease, certain forms of cancer and ageing, possibly by preventing initial DNA damage. Therefore, we investigated the protective effects of crude extract, ethyl acetate fraction and flavonoids (quercetin, quercitrin, isoquercitrin and rutin) isolated from the leaves from Scutia buxifolia against chromosome damage induced by H2O2 in human lymphocytes by analyzing cellular growth rate, cell viability, mitotic index and chromosomal instability. We found a differential response among the compounds tested, with the ethyl acetate fraction being more effective than the crude extract, a difference perhaps related to the presence of the antioxidants identified and quantified by HPLC/DAD. In genera