Publication Bias in Laboratory Animal Research A Survey on Magnitude, Drivers, Consequences and Potential Solutions 英文参考文献.docVIP

PublicationBiasinLaboratoryAnimalResearch:ASurvey onMagnitude,Drivers,ConsequencesandPotential Solutions GerbenterRiet1*,DanielA.Korevaar1,MarliesLeenaars2,PeterJ.Sterk3,CornelisJ.F.VanNoorden4, LexM.Bouter5,Rene′ Lutter3,RonaldP.OudeElferink6,LottyHooft7 1 Department of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands,2 3R Research Centre, Central Animal Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands,3 Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands,4 Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands,5 Executive Board, VU University, Amsterdam, The Netherlands,6 Tytgat Institute for Liver and Intestinal Research Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands,7 Dutch Cochrane Centre, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Abstract Context: Publication bias jeopardizes evidence-based medicine, mainly through biased literature syntheses. Publication bias may also affect laboratory animal research, but evidence is scarce. Objectives: To assess the opinion of laboratory animal researchers on the magnitude, drivers, consequences and potential solutions for publication bias. And to explore the impact of size of the animals used, seniority of the respondent, working in a for-profit organization and type of research (fundamental, pre-clinical, or both) on those opinions. Design: Internet-based survey. Setting: All animal laboratories in The Netherlands. Participants: Laboratory animal researchers. Main Outcome Measure(s): Median (interquartile ranges) strengths of beliefs on 5 and 10-point scales (1: totally unimportant to 5 or 10: extremely important). Results: Overall, 454 researchers