Public-Health and Individual Approaches to Antiretroviral Therapy Township South Africa and Switzerland Compared 英文参考文献.docVIP

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Public-Health and Individual Approaches to Antiretroviral Therapy Township South Africa and Switzerland Compared 英文参考文献.doc

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Public-Health and Individual Approaches to Antiretroviral Therapy Township South Africa and Switzerland Compared 英文参考文献

o PL SMEDICINE Public-HealthandIndividualApproachesto AntiretroviralTherapy:TownshipSouthAfrica andSwitzerlandCompared Olivia Keiser1,Catherine Orrell2,Matthias Egger1,3*,Robin Wood2,Martin W. G.Brinkhof1,Hansjakob Furrer4, Gilles van Cutsem5,Bruno Ledergerber6,Andrew Boulle7,for the Swiss HIV Cohort Study (SHCS) and the International Epidemiologic Databases to Evaluate AIDS inSouthern Africa (IeDEA-SA) 1InstituteofSocialandPreventiveMedicine(ISPM),UniversityofBern,Bern,Switzerland,2TheDesmondTutuHIVCentre,InstituteofInfectiousDiseaseandMolecular Medicine,UniversityofCapeTown,CapeTown,WesternCape,SouthAfrica,3DepartmentofSocialMedicine,UniversityofBristol,Bristol,UnitedKingdom,4Divisionof Infectious Diseases, University Hospital, University of Bern, Bern, Switzerland, 5 Khayelitsha Site B, Me′decins Sans Frontie`res, Cape Town, Western Cape, South Africa, 6DivisionofInfectiousDiseases,UniversityHospitalZu¨rich,Zu¨rich,Switzerland,7SchoolofPublicHealthandFamilyMedicine,UniversityofCapeTown,SouthAfrica Funding:Thisstudywassupported bytheNationalInstituteofAllergy andInfectiousDiseases(grant1U01 AI069924–01)andbytheSwissHIV CohortStudy,throughtheSwiss NationalScienceFoundation.The fundershadnoroleinstudydesign, datacollectionandanalysis,decision topublish,orpreparationofthe manuscript ABSTRACT Background The provision of highly active antiretroviral therapy (HAART) in resource-limited settings followsapublichealthapproach,whichischaracterisedbyalimitednumberofregimensand the standardisation of clinical and laboratory monitoring. In industrialized countries doctors prescribefromthefullrangeofavailableantiretroviraldrugs,supportedbyresistancetesting and frequent laboratory monitoring. We compared virologic response, changes to first-line regimens, and mortality in HIV-infected patients starting HAART in South Africa and Switzerland. CompetingInterests:Seesectionat endofmanuscript. AcademicEditor:DavidBangsberg, SanFranciscoGeneralHospital, UnitedStatesofAmerica Meth