Pyrazole Carbohydrazide Derivatives of Pharmaceutical Interest 英文参考文献.docVIP

Pyrazole Carbohydrazide Derivatives of Pharmaceutical Interest 英文参考文献.doc

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Pyrazole Carbohydrazide Derivatives of Pharmaceutical Interest 英文参考文献

Pharmaceuticals 2012, 5, 317-324; doi:10.3390/ph5030317 OPEN ACCESS Pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Pyrazole Carbohydrazide Derivatives of Pharmaceutical Interest Luiza Rosaria Sousa Dias * and Raquel Rocha Silva Salvador Laboratório de Química Medicinal (LQMed), Faculdade de Farmácia, Universidade Federal Fluminense (UFF), Rua Mário Viana, 523, Santa Rosa, Niterói 24241-000, RJ, Brazil * Author to whom correspondence should be addressed; E-Mail: ldias@vm.uff.br; Tel.: +55-21-2629-9588; Fax: +55-21-2629-9578. Received: 6 February 2012; in revised form: 9 March 2012 / Accepted: 12 March 2012 / Published: 16 March 2012 Abstract: The main purpose of this paper is to provide an insight into the biological activities of pyrazole derivatives which contain the carbohydrazide moiety. Keywords: pyrazole; carbohydrazide; biological activity 1. Introduction Clinically biological activity is the result of a chemical compound’s interaction with a human organism. The biological activity is dependent upon the compound’s structure and its physical-chemical characteristics, as well as the biological entity and its mode of therapeutic treatment. Nonetheless, many times chemical compounds reveal a spectrum of different types of biological activity. Some of them are useful in the treatment of definite diseases, where others may cause various side and toxic effects. This complex of activities caused by the chemical compound in biological entities is called the “biological activity spectrum of the substance”. Hydrazides, carbohydrazides and similar compounds are well known as useful building blocks for the synthesis of a variety of heterocyclic rings. A large number of heterocyclic carbohydrazides and their derivatives are reported to exhibit significant biological activities [1,2] and the carbohydrazide function represents an important pharmacophoric group in several classes of ther

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