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Pyrazole Carbohydrazide Derivatives of Pharmaceutical Interest 英文参考文献
Pharmaceuticals 2012, 5, 317-324; doi:10.3390/ph5030317
OPEN ACCESS
Pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
Pyrazole Carbohydrazide Derivatives of Pharmaceutical Interest
Luiza Rosaria Sousa Dias * and Raquel Rocha Silva Salvador
Laboratório de Química Medicinal (LQMed), Faculdade de Farmácia, Universidade Federal Fluminense
(UFF), Rua Mário Viana, 523, Santa Rosa, Niterói 24241-000, RJ, Brazil
* Author to whom correspondence should be addressed; E-Mail: ldias@vm.uff.br;
Tel.: +55-21-2629-9588; Fax: +55-21-2629-9578.
Received: 6 February 2012; in revised form: 9 March 2012 / Accepted: 12 March 2012 /
Published: 16 March 2012
Abstract: The main purpose of this paper is to provide an insight into the biological
activities of pyrazole derivatives which contain the carbohydrazide moiety.
Keywords: pyrazole; carbohydrazide; biological activity
1. Introduction
Clinically biological activity is the result of a chemical compound’s interaction with a human
organism. The biological activity is dependent upon the compound’s structure and its physical-chemical
characteristics, as well as the biological entity and its mode of therapeutic treatment. Nonetheless,
many times chemical compounds reveal a spectrum of different types of biological activity. Some of
them are useful in the treatment of definite diseases, where others may cause various side and toxic
effects. This complex of activities caused by the chemical compound in biological entities is called the
“biological activity spectrum of the substance”.
Hydrazides, carbohydrazides and similar compounds are well known as useful building blocks for
the synthesis of a variety of heterocyclic rings. A large number of heterocyclic carbohydrazides and
their derivatives are reported to exhibit significant biological activities [1,2] and the carbohydrazide
function represents an important pharmacophoric group in several classes of ther
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